The aim of this paper was to propose a novel in silico mixed elasto-hydrodynamic lubrication model with the purpose of wear prediction in Total Hip Replacements (THRs). The model considers the progressive wear contribution in the calculation of the meatus filled by the non-Newtonian synovial fluid. The results were referred to the gait cycle kinematics, calculated by using musculoskeletal multibody software, while the loading was assumed by literature in vivo measurements. The simulations allow evaluating the fluid and the contact pressure fields and the acetabular cup wear over the time. The results were obtained considering a Ultra High Molecular Weight PolyEthylene, UHMWPE, cup and were compared with results from the literature, showing a good agreement in terms of total volume wear of the cup.
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