A supercritical CO2 (SC-CO2) assisted phase inversion process was tested to load a fructose exopolysaccharide with amphiphilic properties (i.e., levan) in membranes of polyvinylidenefluoride-cohexafluoropropylene (PVDF-HFP). The aim was to investigate the effect of levan on the morphological and biological properties of PVDF-HFP membranes. Different loadings of levan from 0 to 50% w/w were tested: PVDF-HFP + levan membranes characterized by a foam-like structure were generated, with an increase of overall porosity from 75 to 90%. The effect of levan addition on mechanical and biological characteristics of PVDF-HFP membranes was also studied: A decrease of the mechanical resistance from 12 to 1 MPa and an increase of cells (colon cancer cell line HTC-116) adhesion from 8% to 35% were measured. In conclusion, SC-CO2 assisted process was able to generate composite structures potentially useful for biological applications, characterized by a homogeneous distribution of levan and by improved biological properties.

A new composite biomaterial obtained by supercritical CO2 assisted process: PVDF-HFP + Levan

Baldino L.;Cardea S.
;
2020

Abstract

A supercritical CO2 (SC-CO2) assisted phase inversion process was tested to load a fructose exopolysaccharide with amphiphilic properties (i.e., levan) in membranes of polyvinylidenefluoride-cohexafluoropropylene (PVDF-HFP). The aim was to investigate the effect of levan on the morphological and biological properties of PVDF-HFP membranes. Different loadings of levan from 0 to 50% w/w were tested: PVDF-HFP + levan membranes characterized by a foam-like structure were generated, with an increase of overall porosity from 75 to 90%. The effect of levan addition on mechanical and biological characteristics of PVDF-HFP membranes was also studied: A decrease of the mechanical resistance from 12 to 1 MPa and an increase of cells (colon cancer cell line HTC-116) adhesion from 8% to 35% were measured. In conclusion, SC-CO2 assisted process was able to generate composite structures potentially useful for biological applications, characterized by a homogeneous distribution of levan and by improved biological properties.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4754861
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