Type 2 diabetesmellitus (T2DM), the prevalent form of diabetes, a heterogeneous,multifactorial disorder related to diminished insulin secretion, insulin resistance and related factors, such as obesity, sedentary lifestyle, stress and aging. The InternationalDiabetes Federation estimates that without any intervention to slowdown the rise in T2DM, there will be at least 700million peoplewith diabetes by 2045. The changes in lifestyle (lack of exercise, junk food) and increase in life expectancy, human facing more challenges from metabolic disorders (Nazarian-Samani et al., 2018; Xiao and Luo, 2018). Among the metabolic diseases, we have the cluster of conditions (hypertension, hyperglycemia, abdominal obesity, and elevated cholesterol or triglyceride levels) that when occur together are called; metabolic syndrome and T2DM (Saklayen, 2018). Medicinal plants are widely used throughout the world especially in the developing countries to manage the metabolic syndrome and T2DM (Chukwuma et al., 2019). The pathophysiological conditions engage metabolic pathways involve hundreds of enzymes, proteins, cofactors; various cells, tissues and organs especially pancreas, liver, gut,muscle, adipose tissue and kidney. It is important to understand the mechanisms underlying the medicinal plants in controlling the metabolic syndrome and T2DM (Demmers et al., 2017; Ota and Ulrih, 2017; Salehi et al., 2019). However, conceptual and methodological challenges exist. Thus, this Research Topic aims to aid to our understanding of the hypoglycemic actions by medicinal plants and derived phytochemicals. Among 27 submitted manuscripts for this Research Topic, only seven manuscripts have been accepted.
Editorial: Mechanisms of Traditional Medicinal Plants Used to Control Type 2 Diabetes or Metabolic Syndrome
De Feo, Vincenzo;
2021-01-01
Abstract
Type 2 diabetesmellitus (T2DM), the prevalent form of diabetes, a heterogeneous,multifactorial disorder related to diminished insulin secretion, insulin resistance and related factors, such as obesity, sedentary lifestyle, stress and aging. The InternationalDiabetes Federation estimates that without any intervention to slowdown the rise in T2DM, there will be at least 700million peoplewith diabetes by 2045. The changes in lifestyle (lack of exercise, junk food) and increase in life expectancy, human facing more challenges from metabolic disorders (Nazarian-Samani et al., 2018; Xiao and Luo, 2018). Among the metabolic diseases, we have the cluster of conditions (hypertension, hyperglycemia, abdominal obesity, and elevated cholesterol or triglyceride levels) that when occur together are called; metabolic syndrome and T2DM (Saklayen, 2018). Medicinal plants are widely used throughout the world especially in the developing countries to manage the metabolic syndrome and T2DM (Chukwuma et al., 2019). The pathophysiological conditions engage metabolic pathways involve hundreds of enzymes, proteins, cofactors; various cells, tissues and organs especially pancreas, liver, gut,muscle, adipose tissue and kidney. It is important to understand the mechanisms underlying the medicinal plants in controlling the metabolic syndrome and T2DM (Demmers et al., 2017; Ota and Ulrih, 2017; Salehi et al., 2019). However, conceptual and methodological challenges exist. Thus, this Research Topic aims to aid to our understanding of the hypoglycemic actions by medicinal plants and derived phytochemicals. Among 27 submitted manuscripts for this Research Topic, only seven manuscripts have been accepted.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
