This article describes new protocols for intermittent hemodialysis, based on a mathematical model for bicarbonate restoring, which ameliorate drawbacks of the standard therapy and allow the nephrologist to design any desired profile of bicarbonate concentration in the patient blood, enabling a safer and more effective treatment. The proposed protocols can be tailored to patient-specific clinical prescriptions, opening the way to highly personalized hemodialysis treatments. This article describes a simpler and more insightful solutions to the same mathematical model considered in previous works, with more straightforward system-theory interpretation. This is relevant as it leads to self-explaining evidences of the underlying physiological mechanisms, which is crucial in order to communicate the model potential to clinicians, not necessarily skilled in advanced math modeling.

Frontiers in hemodialysis part II: Toward personalized and optimized therapy

Marano S.
;
2020

Abstract

This article describes new protocols for intermittent hemodialysis, based on a mathematical model for bicarbonate restoring, which ameliorate drawbacks of the standard therapy and allow the nephrologist to design any desired profile of bicarbonate concentration in the patient blood, enabling a safer and more effective treatment. The proposed protocols can be tailored to patient-specific clinical prescriptions, opening the way to highly personalized hemodialysis treatments. This article describes a simpler and more insightful solutions to the same mathematical model considered in previous works, with more straightforward system-theory interpretation. This is relevant as it leads to self-explaining evidences of the underlying physiological mechanisms, which is crucial in order to communicate the model potential to clinicians, not necessarily skilled in advanced math modeling.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4770997
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