A variety of cyclen and hexacyclen derivatives decorated with (S)-1-phenylethyl side chains or (S)-pyrrolidine units have been preparedviaa reductive approach from the corresponding cyclic peptoids containingN-(S)-(1-phenylethyl)glycine andl-proline residues. Spectroscopic and DFT studies on their Na+complexes show that point chirality and ring size play a crucial role in controlling the structural dynamism of 1,2-diaminoethylene units and pendant arms. The detection of highly symmetricC4- andC3-symmetric metalated species demonstrates that a full understanding of the relationship between the structure and conformational properties of peraza-macrocyclic metal complexes is possible.
Structural dynamism of chiral sodium peraza-macrocycle complexes derived from cyclic peptoids
Schettini R.Membro del Collaboration Group
;D'Amato A.Membro del Collaboration Group
;Araszczuk A. M.Membro del Collaboration Group
;Della Sala G.Membro del Collaboration Group
;Costabile C.Membro del Collaboration Group
;D'Ursi A. M.Membro del Collaboration Group
;Grimaldi M.Membro del Collaboration Group
;Izzo I.
;De Riccardis F.
2021-01-01
Abstract
A variety of cyclen and hexacyclen derivatives decorated with (S)-1-phenylethyl side chains or (S)-pyrrolidine units have been preparedviaa reductive approach from the corresponding cyclic peptoids containingN-(S)-(1-phenylethyl)glycine andl-proline residues. Spectroscopic and DFT studies on their Na+complexes show that point chirality and ring size play a crucial role in controlling the structural dynamism of 1,2-diaminoethylene units and pendant arms. The detection of highly symmetricC4- andC3-symmetric metalated species demonstrates that a full understanding of the relationship between the structure and conformational properties of peraza-macrocyclic metal complexes is possible.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
