A variety of cyclen and hexacyclen derivatives decorated with (S)-1-phenylethyl side chains or (S)-pyrrolidine units have been preparedviaa reductive approach from the corresponding cyclic peptoids containingN-(S)-(1-phenylethyl)glycine andl-proline residues. Spectroscopic and DFT studies on their Na+complexes show that point chirality and ring size play a crucial role in controlling the structural dynamism of 1,2-diaminoethylene units and pendant arms. The detection of highly symmetricC4- andC3-symmetric metalated species demonstrates that a full understanding of the relationship between the structure and conformational properties of peraza-macrocyclic metal complexes is possible.

Structural dynamism of chiral sodium peraza-macrocycle complexes derived from cyclic peptoids

Schettini R.
Membro del Collaboration Group
;
D'Amato A.
Membro del Collaboration Group
;
Araszczuk A. M.
Membro del Collaboration Group
;
Della Sala G.
Membro del Collaboration Group
;
Costabile C.
Membro del Collaboration Group
;
D'Ursi A. M.
Membro del Collaboration Group
;
Grimaldi M.
Membro del Collaboration Group
;
Izzo I.
;
De Riccardis F.
2021

Abstract

A variety of cyclen and hexacyclen derivatives decorated with (S)-1-phenylethyl side chains or (S)-pyrrolidine units have been preparedviaa reductive approach from the corresponding cyclic peptoids containingN-(S)-(1-phenylethyl)glycine andl-proline residues. Spectroscopic and DFT studies on their Na+complexes show that point chirality and ring size play a crucial role in controlling the structural dynamism of 1,2-diaminoethylene units and pendant arms. The detection of highly symmetricC4- andC3-symmetric metalated species demonstrates that a full understanding of the relationship between the structure and conformational properties of peraza-macrocyclic metal complexes is possible.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4771854
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