The synthesis of multifunctionalized β-ketoesters has been achieved by using molecular iodine as a catalyst under very mild conditions. The vinylogous addition of Chan's diene 1 to carbonyl and carbonyl-related compounds (aldehydes, ketones, imines and acetals) occurred with high efficiencies and with complete γ-selectivity, giving a useful method for the synthesis of interesting libraries of different δ-functionalized β-ketoesters. © 2011 Elsevier Ltd. All rights reserved.
Synthesis of multifunctionalized building blocks via vinylogous addition of Chan's diene to carbonyl and carbonyl-related electrophiles, mediated by molecular iodine
Villano R.;Acocella M. R.Investigation
;Scettri A.
2011-01-01
Abstract
The synthesis of multifunctionalized β-ketoesters has been achieved by using molecular iodine as a catalyst under very mild conditions. The vinylogous addition of Chan's diene 1 to carbonyl and carbonyl-related compounds (aldehydes, ketones, imines and acetals) occurred with high efficiencies and with complete γ-selectivity, giving a useful method for the synthesis of interesting libraries of different δ-functionalized β-ketoesters. © 2011 Elsevier Ltd. All rights reserved.File in questo prodotto:
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