Seven new terpenoids, namely, guaiane (1-4), eudesmane (5), and bisabolane (6) sesquiterpenoids and a furanone(7), were isolated from the aerial parts of Ammoides atlantica, a herbaceous plant growing in Algeria, together with eight known compounds. All metabolites were characterized by their 1D and 2D NMR and HRESIMS data. A combined DFT/NMR method wasapplied to study the relative configurations of1-4,6, and7. All compounds, except2, were assayed against MCF-7, A375, A549,HaCaT, and Jurkat cell lines. Compounds8,10, and11induced a dose-dependent reduction in cell viability with different potencyon almost all cell lines used. The most active compounds,8and10, were studied to assess their potential apoptotic effects and cell cycle inhibition
Cytotoxic Sesquiterpenoids from Ammoides atlantica Aerial Parts
Parisi, ValentinaInvestigation
;Franceschelli, SilviaMethodology
;Pecoraro, MichelaInvestigation
;Pascale, MariaResources
;Bifulco, GiuseppeSupervision
;De Tommasi, Nunziatina
Conceptualization
;
2022-01-01
Abstract
Seven new terpenoids, namely, guaiane (1-4), eudesmane (5), and bisabolane (6) sesquiterpenoids and a furanone(7), were isolated from the aerial parts of Ammoides atlantica, a herbaceous plant growing in Algeria, together with eight known compounds. All metabolites were characterized by their 1D and 2D NMR and HRESIMS data. A combined DFT/NMR method wasapplied to study the relative configurations of1-4,6, and7. All compounds, except2, were assayed against MCF-7, A375, A549,HaCaT, and Jurkat cell lines. Compounds8,10, and11induced a dose-dependent reduction in cell viability with different potencyon almost all cell lines used. The most active compounds,8and10, were studied to assess their potential apoptotic effects and cell cycle inhibitionI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
