Since the official inclusion of sex and gender in biomedical research, gender differences are recognized as important determinants of the risk of developing neurode-generative diseases in the healthy population. In this review, we collected the available evidence on gender differences in Parkinson’s disease regarding motor and non-motor symp-toms, with a focus on neuropsychiatric symptoms. Finally, we will briefly discuss the issue of pregnancy for parkinso-nian women. Though starting with a more benign pheno-type, as the disease progresses, women are at higher risk of developing disabling treatment-related complications, such as motor and non-motor fluctuations as well as dyskinesia, compared with men. Taken together, these findings chal-lenge the definition of a more benign phenotype in women. Improving our understanding in gender differences in Par-kinson’s disease may result in improving our ability to tailor disease treatment and management.

The role of gender in parkinson’s disease

Picillo M.;Pellecchia M. T.
2017

Abstract

Since the official inclusion of sex and gender in biomedical research, gender differences are recognized as important determinants of the risk of developing neurode-generative diseases in the healthy population. In this review, we collected the available evidence on gender differences in Parkinson’s disease regarding motor and non-motor symp-toms, with a focus on neuropsychiatric symptoms. Finally, we will briefly discuss the issue of pregnancy for parkinso-nian women. Though starting with a more benign pheno-type, as the disease progresses, women are at higher risk of developing disabling treatment-related complications, such as motor and non-motor fluctuations as well as dyskinesia, compared with men. Taken together, these findings chal-lenge the definition of a more benign phenotype in women. Improving our understanding in gender differences in Par-kinson’s disease may result in improving our ability to tailor disease treatment and management.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4807700
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