BackgroundMultiple surgical alternatives are available to treat breast cancer-related lymphedema (BCRL) providing a variable spectrum of outcomes. This study aimed to present the breast cancer-related lymphedema multidisciplinary approach (B-LYMA) to systematically treat BCRL. MethodsSeventy-eight patients presenting with BCRL between 2017 and 2021 were included. The average age and BMI were 49.4 +/- 7.8 years and 28.1 +/- 3.5 kg/m(2), respectively. Forty patients had lymphedema ISL stage II (51.3%) and 38 had stage III (48.7%). The mean follow-up was 26.4 months. Treatment was selected according to the B-LYMA algorithm, which aims to combine physiologic and excisional procedures according to the preoperative evaluation of patients. All patients had pre- and postoperative complex decongestive therapy (CDT). ResultsStage II patients were treated with lymphaticovenous anastomosis (LVA) (n = 18), vascularized lymph node transfer (VLNT) (n = 12), and combined DIEP flap and VLNT (n = 10). Stage III patients underwent combined suction-assisted lipectomy (SAL) and LVA (n = 36) or combined SAL and VLNT (n = 2). Circumferential reduction rates (CRR) were comparable between patients treated with LVA (56.5 +/- 8.4%), VLNT (54.4 +/- 10.2%), and combined VLNT-DIEP flap (56.5 +/- 3.9%) (p > .05). In comparison to LVA, VLNT, and combined VLNT-DIEP flap, combined SAL-LVA exhibited higher CRRs (85 +/- 10.5%, p < .001). The CRR for combined SAL-VLNT was 75 +/- 8.5%. One VLNT failed and minor complications occurred in the combined DIEP-VLNT group. ConclusionThe B-LYMA protocol directs the treatment of BCRL according to the lymphatic system's condition. In advanced stages where a single physiologic procedure is not sufficient, additional excisional surgery is implemented. Preoperative and postoperative CDT is mandatory to improve the outcomes.

The breast cancer-related lymphedema multidisciplinary approach: Algorithm for conservative and multimodal surgical treatment

Losco, Luigi;
2022-01-01

Abstract

BackgroundMultiple surgical alternatives are available to treat breast cancer-related lymphedema (BCRL) providing a variable spectrum of outcomes. This study aimed to present the breast cancer-related lymphedema multidisciplinary approach (B-LYMA) to systematically treat BCRL. MethodsSeventy-eight patients presenting with BCRL between 2017 and 2021 were included. The average age and BMI were 49.4 +/- 7.8 years and 28.1 +/- 3.5 kg/m(2), respectively. Forty patients had lymphedema ISL stage II (51.3%) and 38 had stage III (48.7%). The mean follow-up was 26.4 months. Treatment was selected according to the B-LYMA algorithm, which aims to combine physiologic and excisional procedures according to the preoperative evaluation of patients. All patients had pre- and postoperative complex decongestive therapy (CDT). ResultsStage II patients were treated with lymphaticovenous anastomosis (LVA) (n = 18), vascularized lymph node transfer (VLNT) (n = 12), and combined DIEP flap and VLNT (n = 10). Stage III patients underwent combined suction-assisted lipectomy (SAL) and LVA (n = 36) or combined SAL and VLNT (n = 2). Circumferential reduction rates (CRR) were comparable between patients treated with LVA (56.5 +/- 8.4%), VLNT (54.4 +/- 10.2%), and combined VLNT-DIEP flap (56.5 +/- 3.9%) (p > .05). In comparison to LVA, VLNT, and combined VLNT-DIEP flap, combined SAL-LVA exhibited higher CRRs (85 +/- 10.5%, p < .001). The CRR for combined SAL-VLNT was 75 +/- 8.5%. One VLNT failed and minor complications occurred in the combined DIEP-VLNT group. ConclusionThe B-LYMA protocol directs the treatment of BCRL according to the lymphatic system's condition. In advanced stages where a single physiologic procedure is not sufficient, additional excisional surgery is implemented. Preoperative and postoperative CDT is mandatory to improve the outcomes.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4812431
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