Abstract: In the last 15 years, the smart materials have aroused considerable interest in the field of bio- medicine and in particular in drug delivery be- cause they have the ability to respond to external stimuli. The central goal of drug delivery is to maximize therapeutic activity while minimizing side effects. (1) After administration of the drug, it is important to deliver the drug selectively to a target organ or tissue so it is essential to follow the path of the drug in our body by chemically binding a fluorescent probe to the polymeric car- rier. (2) For this purpose a promising fluorescent probe is represented by coumarin. It is an oxygen-containing heterocycle belonging to the lactone family. Although this natural compound occurs in various parts of different plants, its highest concentration can be found in fruits, roots, stems, and leaves. Apart from plants, mi- croorganisms are also a natural source of couma- rins. The isolated coumarins are mostly biologi- cally active and show antimicrobial, antibacte- rial, antifungal and antiviral activity. (3) We re- port the polymerization by ATRP (atomic trans- fer radical polymerization) using a molar ratio of monomer 7–methacryloyl oxycoumarin) (MAOC) and initiator of 10 to 1, 20 to 1 and 40 to 1. To obtain a copolymer, the homopolymer (PMAOC) was first synthesized by ATRP and then 2-dimethyl amino ethylmethacrylate (DMAEMA) was added. A sequential polymeri- zation was then followed by operating with a mo- lar ratio between the two monomers (MAOC and DMAEMA) of 1 to 10. The block copolymers have a different length of the fluorescent block chain where the fluorescent part (PMAOC) has only the role of tracing the path of the drug, while DMAEMA is the carrier with cytotoxic activity.
Synthesis and characterization of smart fluorescent polymers for biomedical applications
Vissia Vitale
;Stefania Pragliola;Fabia Grisi;Chiara Costabile
2022-01-01
Abstract
Abstract: In the last 15 years, the smart materials have aroused considerable interest in the field of bio- medicine and in particular in drug delivery be- cause they have the ability to respond to external stimuli. The central goal of drug delivery is to maximize therapeutic activity while minimizing side effects. (1) After administration of the drug, it is important to deliver the drug selectively to a target organ or tissue so it is essential to follow the path of the drug in our body by chemically binding a fluorescent probe to the polymeric car- rier. (2) For this purpose a promising fluorescent probe is represented by coumarin. It is an oxygen-containing heterocycle belonging to the lactone family. Although this natural compound occurs in various parts of different plants, its highest concentration can be found in fruits, roots, stems, and leaves. Apart from plants, mi- croorganisms are also a natural source of couma- rins. The isolated coumarins are mostly biologi- cally active and show antimicrobial, antibacte- rial, antifungal and antiviral activity. (3) We re- port the polymerization by ATRP (atomic trans- fer radical polymerization) using a molar ratio of monomer 7–methacryloyl oxycoumarin) (MAOC) and initiator of 10 to 1, 20 to 1 and 40 to 1. To obtain a copolymer, the homopolymer (PMAOC) was first synthesized by ATRP and then 2-dimethyl amino ethylmethacrylate (DMAEMA) was added. A sequential polymeri- zation was then followed by operating with a mo- lar ratio between the two monomers (MAOC and DMAEMA) of 1 to 10. The block copolymers have a different length of the fluorescent block chain where the fluorescent part (PMAOC) has only the role of tracing the path of the drug, while DMAEMA is the carrier with cytotoxic activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
