Topical administration is the preferred route for the controlled release of active compounds since it reduces side effects typical of other administration methods. The use of polymer blends is a way to modulate drug release from a topical device. The blends ensure modulation of a wide range of properties, such as mechanical properties, water sorption, and degradation. This paper proposes blends of poly(lactide acid) (PLA), and Poly(butylene adipate-co-terephthalate) (PBAT), for the topical release of caffeine, a molecule with anti-inflammatory, antioxidant, and anticellulite activities. PBAT/PLA blends are optimized for compatibility between the two polymers, mechanical properties, and drug release rate. Blends with a higher amount of PBAT show the best performance regarding polymer compatibility. The blends undergo supercritical CO2-assisted caffeine impregnation. This process assures homogeneous dispersion of caffeine into the polymer matrix. The ratios 45/55 and 55/45 PBAT/PLA show the best performance in terms of caffeine release (complete caffeine release within 25 h). Caffeine is released into three steps: a burst effect due to the caffeine dispersed over the film surface, a slower release due to the caffeine dispersed in the polymer matrix, and a fast release due to the increase of polymer degradation rate induced by caffeine presence.In this paper, anticellulite devices are proposed. The polymer matrix constituting the patch is given by a poly(lactide acid/poly(butylene adipate-co-terephthalate) (PLA/PBAT) blend (prepared at different weight ratios); the patches are impregnated with caffeine via a supercritical impregnation. The active ingredient can be released in a controlled manner when the patches are prepared at an optimal PLA/PBAT percentage.image

PBAT/PLA Films and Supercritical Impregnation of Caffeine for Potential Application in Anticellulite Tools

Liparoti, Sara;Mottola, Stefania;De Marco, Iolanda
;
Pantani, Roberto
2023-01-01

Abstract

Topical administration is the preferred route for the controlled release of active compounds since it reduces side effects typical of other administration methods. The use of polymer blends is a way to modulate drug release from a topical device. The blends ensure modulation of a wide range of properties, such as mechanical properties, water sorption, and degradation. This paper proposes blends of poly(lactide acid) (PLA), and Poly(butylene adipate-co-terephthalate) (PBAT), for the topical release of caffeine, a molecule with anti-inflammatory, antioxidant, and anticellulite activities. PBAT/PLA blends are optimized for compatibility between the two polymers, mechanical properties, and drug release rate. Blends with a higher amount of PBAT show the best performance regarding polymer compatibility. The blends undergo supercritical CO2-assisted caffeine impregnation. This process assures homogeneous dispersion of caffeine into the polymer matrix. The ratios 45/55 and 55/45 PBAT/PLA show the best performance in terms of caffeine release (complete caffeine release within 25 h). Caffeine is released into three steps: a burst effect due to the caffeine dispersed over the film surface, a slower release due to the caffeine dispersed in the polymer matrix, and a fast release due to the increase of polymer degradation rate induced by caffeine presence.In this paper, anticellulite devices are proposed. The polymer matrix constituting the patch is given by a poly(lactide acid/poly(butylene adipate-co-terephthalate) (PLA/PBAT) blend (prepared at different weight ratios); the patches are impregnated with caffeine via a supercritical impregnation. The active ingredient can be released in a controlled manner when the patches are prepared at an optimal PLA/PBAT percentage.image
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4859891
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