Currently, the research in the biomedical field is going toward the development of cutting-edge materials applicable for different purposes, from diagnostics to therapeutic treatments. In this scenario, the electrospinning process stands out as one of the processes able to produce biocompatible nanofibers, mimicking the human tissue, with relative ease and scalability. The obtained membranes can be efficiently used, for example, for wound dressing or for treatment after surgery. In the current study, electrospun membranes made of Polycaprolactone (PCL) loaded with different Fe3O4 nanoparticles percentages (from 0% to 10% in weight) are produced according to the procedure of Guadagno et al. and the thermal stability and typical transitions have been evaluated via thermogravimetric analysis and differential scanning calorimetry. The mechanical characteristics of the nanocomposites have been evaluated with an innovative approach, using the Harmonix-AFM, through which it is possible to obtain an accurate mechanical mapping of the nanofiber surfaces.
Thermal analysis and nanometric mechanical map of electrospun membranes loaded with Fe3O4 nanoparticles
R. Longo;R. Pantani;V. Speranza;M. Raimondo;L. Guadagno
2022
Abstract
Currently, the research in the biomedical field is going toward the development of cutting-edge materials applicable for different purposes, from diagnostics to therapeutic treatments. In this scenario, the electrospinning process stands out as one of the processes able to produce biocompatible nanofibers, mimicking the human tissue, with relative ease and scalability. The obtained membranes can be efficiently used, for example, for wound dressing or for treatment after surgery. In the current study, electrospun membranes made of Polycaprolactone (PCL) loaded with different Fe3O4 nanoparticles percentages (from 0% to 10% in weight) are produced according to the procedure of Guadagno et al. and the thermal stability and typical transitions have been evaluated via thermogravimetric analysis and differential scanning calorimetry. The mechanical characteristics of the nanocomposites have been evaluated with an innovative approach, using the Harmonix-AFM, through which it is possible to obtain an accurate mechanical mapping of the nanofiber surfaces.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.