Sorption of dicarboxylic acid molecules of pharmaceutical interest such as azelaic acid (AzA), in syndiotactic polystyrene (sPS) films presenting δ and ε nanoporous crystalline structure, is reported. Fourier Transform Infrared (FTIR), Polarized FTIR and Wide-Angle X-ray diffraction (WAXD) patterns on axially oriented sPS films has been performed to verify their sorption in crystalline lattices resulting in the formation of co-crystalline (CC) phases. Experimental evidence provides that AzA molecules can be included in the crystalline nanochannels of ε phase both as isolated and hydrogen-bonded molecules whereas they are only dissolved in the amorphous phase of δ samples.
Co-Crystalline Phases of Syndiotactic Polystyrene with Azelaic Acid Molecules of Pharmaceutical Interest
Cozzolino A.
;Daniel C.;Rizzo P.
2024-01-01
Abstract
Sorption of dicarboxylic acid molecules of pharmaceutical interest such as azelaic acid (AzA), in syndiotactic polystyrene (sPS) films presenting δ and ε nanoporous crystalline structure, is reported. Fourier Transform Infrared (FTIR), Polarized FTIR and Wide-Angle X-ray diffraction (WAXD) patterns on axially oriented sPS films has been performed to verify their sorption in crystalline lattices resulting in the formation of co-crystalline (CC) phases. Experimental evidence provides that AzA molecules can be included in the crystalline nanochannels of ε phase both as isolated and hydrogen-bonded molecules whereas they are only dissolved in the amorphous phase of δ samples.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.