Development of a Novel Glucose Sensor Based on Fe3O4@SnO2@ZIF-67 Nanocomposite

An innovative approach for the colorimetric detection of glucose is reported, utilizing Fe3O4@ SnO2@ZIF-67 nanocomposites, which leverage the catalytic properties of Fe3O4 nanoparticles enhanced by SnO2 and encapsulated within a Zeolitic Imidazolate Frameworks-67 (ZIF-67) metal-organic framework. These composites exhibit superior stability, efficiency, and catalytic activity compared to natural enzymes, effectively oxidizing 3,3',5,5'-Tetramethylbenzidine (TMB) in the presence of H2O2 for colorimetric glucose detection. The nanocomposites achieved optimal catalytic activity at pH 4 and 45 degrees C, with a catalyst concentration of 1 mg/mL. The UV-vis absorbance of oxidized TMB at 652 nm confirmed their peroxidase-like activity, comparable to horseradish peroxidase. This sensor addresses key challenges in diabetes management, representing a significant advancement in cost-effective, stable, and efficient biosensing technologies.