Base-mediated reactions between hydroxypyrones or isochroman-3,4-diones and allenoates or butynoates allow for the direct synthesis of various 1,2,3-substituted phenols and naphthols under mild conditions. These transformations are proposed to proceed first via a [4 + 2]-cycloaddition of the starting materials, followed by an immediate decarboxylation/re-aromatization process.
Syntheses of 1,2,3-functionalized naphthols and phenols by decarboxylative cycloaddition/aromatization reactions of α-oxygenated lactones with allenoates or electron-deficient alkynes
Mousavi, Mohammad Sadeq;Massa, Antonio
;Waser, Mario
2026
Abstract
Base-mediated reactions between hydroxypyrones or isochroman-3,4-diones and allenoates or butynoates allow for the direct synthesis of various 1,2,3-substituted phenols and naphthols under mild conditions. These transformations are proposed to proceed first via a [4 + 2]-cycloaddition of the starting materials, followed by an immediate decarboxylation/re-aromatization process.File in questo prodotto:
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