ESOPHAGEAL ENDOSCOPIC FINDINGS IN ADULT COELIAC PATIENTS P. Iovino1, F. Sabbatini1, C. Bucci1, A. Vicidomini1, D. Consalvo1, C. Ciacci1 1Medicina clinica e sperimentale, Gastroenterologia, napoli, Italy INTRODUCTION: We have previously shown that adult coeliac patients with steatorrhoea had a higher prevalence of oesophageal symptoms and a lowered lower oesophageal sphincter pressure at manometry in spite of a normal oesophageal mucosa at endoscopy. Recently, it has been shown that endoscopic oesophagitis was two fold increased in coeliac subjects on normal diet, when compared to non-coeliac dyspeptic individuals, and gluten free diet had a beneficial effect on symptoms relapse. AIMS & METHODS: Aim of the present study was to investigate the prevalence of oesophageal symptoms and endoscopic findings in a large cohort of adult coeliac patients on normal and gluten free diet. 1254 coeliac subjects (951 F) median age (29.6 ± 11.6) yrs that underwent upper endoscopy for diagnosis or follow up of coeliac disease were retrospectively studied. A complete medical work up was offered to all of them. We scored the presence of dyspeptic symptoms, oesophagitis (according to Savary-Miller) and the presence of hiatal hernia RESULTS: 192 (15 %) patients were on gluten free diet and 1062 (85 %) on normal diet. The overall prevalence of dyspeptic symptoms, oesophagitis and hiatal hernia were 30.0 %, 1.6 %, and 10.8 % , respectively. In patients on gluten free diet and in patients on normal diet the prevalence of dyspeptic symptoms was 15.0 % and 33.0 % (p < 0.01), of oesophagitis 2.0 % and 1.6 % (p = NS), of hiatal hernia 12.5 % and 12.8 % (p = NS). No association was found in oesophagitis and hiatal hernia between coeliac patients with childhood diagnosis and coeliac patients newly diagnosed. A significantly higher BMI was found in patients with hiatal hernia. CONCLUSION: we confirmed in a larger cohort of coeliac patients a higher prevalence of dyspeptic symptoms on normal diet. The overall prevalence of oesophagitis and hiatal hernia was low, irrespective of gluten free diet GUT 2004; 53 Suppl IV A200
Esophageal endoscopic findings in adult coeliac patients
IOVINO, Paola;BUCCI, CRISTINA;CIACCI, Carolina
2004-01-01
Abstract
ESOPHAGEAL ENDOSCOPIC FINDINGS IN ADULT COELIAC PATIENTS P. Iovino1, F. Sabbatini1, C. Bucci1, A. Vicidomini1, D. Consalvo1, C. Ciacci1 1Medicina clinica e sperimentale, Gastroenterologia, napoli, Italy INTRODUCTION: We have previously shown that adult coeliac patients with steatorrhoea had a higher prevalence of oesophageal symptoms and a lowered lower oesophageal sphincter pressure at manometry in spite of a normal oesophageal mucosa at endoscopy. Recently, it has been shown that endoscopic oesophagitis was two fold increased in coeliac subjects on normal diet, when compared to non-coeliac dyspeptic individuals, and gluten free diet had a beneficial effect on symptoms relapse. AIMS & METHODS: Aim of the present study was to investigate the prevalence of oesophageal symptoms and endoscopic findings in a large cohort of adult coeliac patients on normal and gluten free diet. 1254 coeliac subjects (951 F) median age (29.6 ± 11.6) yrs that underwent upper endoscopy for diagnosis or follow up of coeliac disease were retrospectively studied. A complete medical work up was offered to all of them. We scored the presence of dyspeptic symptoms, oesophagitis (according to Savary-Miller) and the presence of hiatal hernia RESULTS: 192 (15 %) patients were on gluten free diet and 1062 (85 %) on normal diet. The overall prevalence of dyspeptic symptoms, oesophagitis and hiatal hernia were 30.0 %, 1.6 %, and 10.8 % , respectively. In patients on gluten free diet and in patients on normal diet the prevalence of dyspeptic symptoms was 15.0 % and 33.0 % (p < 0.01), of oesophagitis 2.0 % and 1.6 % (p = NS), of hiatal hernia 12.5 % and 12.8 % (p = NS). No association was found in oesophagitis and hiatal hernia between coeliac patients with childhood diagnosis and coeliac patients newly diagnosed. A significantly higher BMI was found in patients with hiatal hernia. CONCLUSION: we confirmed in a larger cohort of coeliac patients a higher prevalence of dyspeptic symptoms on normal diet. The overall prevalence of oesophagitis and hiatal hernia was low, irrespective of gluten free diet GUT 2004; 53 Suppl IV A200I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
