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EnglishWe report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN10627.
| Titolo: | Neuronorm is a potent and water soluble neurokinin A receptor antagonist. |
| Autori: | |
| Data di pubblicazione: | 1998 |
| Rivista: | |
| Abstract: | We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN10627. |
| Handle: | http://hdl.handle.net/11386/3127934 |
| Appare nelle tipologie: | 1.1 Articoli su Rivista |
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