In order to investigate experimentally possible synergism between a passiflora extract and a kava extract, both were tested individually and in combination in a controlled pharmacological study in the mouse. The effects on amphetamine-induced hypermotility and on barbiturate-sleeping-time were studied. The results show that both drugs exert statistically significant sedative effects. Their nature differed with each single extract. While the sedative effect of kava manifested itself as a pronounced reduction in amphetamine-induced hypermotility relatively greater than that of passiflora, the reverse was the case for prolongation of barbiturate-sleeping-time which was greater with passiflora than kava. Synergism between the two drugs was observed when the two extracts were administered simultaneously.
Experimental investigations of the synergistic-sedative effect of passiflora and kava
CAPASSO, Anna;PINTO, Aldo
1995-01-01
Abstract
In order to investigate experimentally possible synergism between a passiflora extract and a kava extract, both were tested individually and in combination in a controlled pharmacological study in the mouse. The effects on amphetamine-induced hypermotility and on barbiturate-sleeping-time were studied. The results show that both drugs exert statistically significant sedative effects. Their nature differed with each single extract. While the sedative effect of kava manifested itself as a pronounced reduction in amphetamine-induced hypermotility relatively greater than that of passiflora, the reverse was the case for prolongation of barbiturate-sleeping-time which was greater with passiflora than kava. Synergism between the two drugs was observed when the two extracts were administered simultaneously.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
