The first enantioselective α-hydroxylation reaction of α-substituted β-ketoamides has been developed by using the commercially available hydroquinine/TBHP system. The tertiary alcohols are obtained in good to high yield and up to 83% ee, which can be improved by a single crystallization.
Enantioselective alfa-hydroxylation of beta-ketoamides
DE FUSCO, CLAUDIA;MENINNO, SARA;TEDESCO, Consiglia;LATTANZI, Alessandra
2013
Abstract
The first enantioselective α-hydroxylation reaction of α-substituted β-ketoamides has been developed by using the commercially available hydroquinine/TBHP system. The tertiary alcohols are obtained in good to high yield and up to 83% ee, which can be improved by a single crystallization.File in questo prodotto:
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