Enantioselective alfa-hydroxylation of beta-ketoamides

The first enantioselective α-hydroxylation reaction of α-substituted β-ketoamides has been developed by using the commercially available hydroquinine/TBHP system. The tertiary alcohols are obtained in good to high yield and up to 83% ee, which can be improved by a single crystallization.



Titolo: Enantioselective alfa-hydroxylation of beta-ketoamides
Autori: 
DE FUSCO, CLAUDIA
MENINNO, Sara
TEDESCO, Consiglia
LATTANZI, Alessandra
Data di pubblicazione: 2013
Rivista: 
ORGANIC & BIOMOLECULAR CHEMISTRY  
Abstract: The first enantioselective α-hydroxylation reaction of α-substituted β-ketoamides has been developed by using the commercially available hydroquinine/TBHP system. The tertiary alcohols are obtained in good to high yield and up to 83% ee, which can be improved by a single crystallization.
Handle: http://hdl.handle.net/11386/3976210
Appare nelle tipologie:1.1.2 Articolo su rivista con ISSN

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http://hdl.handle.net/11386/3976210
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