The first enantioselective α-hydroxylation reaction of α-substituted β-ketoamides has been developed by using the commercially available hydroquinine/TBHP system. The tertiary alcohols are obtained in good to high yield and up to 83% ee, which can be improved by a single crystallization.
Titolo: | Enantioselective alfa-hydroxylation of beta-ketoamides | |
Autori: | ||
Data di pubblicazione: | 2013 | |
Rivista: | ||
Abstract: | The first enantioselective α-hydroxylation reaction of α-substituted β-ketoamides has been developed by using the commercially available hydroquinine/TBHP system. The tertiary alcohols are obtained in good to high yield and up to 83% ee, which can be improved by a single crystallization. | |
Handle: | http://hdl.handle.net/11386/3976210 | |
Appare nelle tipologie: | 1.1.2 Articolo su rivista con ISSN |
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