Liver biopsy is still the gold standard procedure for obtaining liver tissue for histopathologic examination and a valuable tool in the diagnosis, prognosis and management of many parenchymal liver diseases. The aim of this position paper is to summarize the current practice of paediatric liver biopsy and make recommendations about its performance.Although histological evaluation of the liver is important in assessing prognosis and in exploring treatment, non-invasive techniques (i.e., imaging, laboratory markers) may replace use of liver histology. The indications for liver biopsy are changing as current knowledge of aetiologies, pathomechanism and therapeutic options in paediatric liver disease are evolving.Adult and paediatric literature was reviewed to assess the existing clinical practice of liver biopsy with focus on the technique, indications, risk of complications and contraindications in paediatrics.This position paper presents types of liver biopsy, indications, complications, contraindications and an essential check list for paediatric liver biopsy.
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