An efficient and gram-scale continuous-flow protocol for the synthesis of the privileged structure 3,4-dihydro-5H-benzo[e][1,4]diazepin-5-one is reported. If compared to the traditional metal mediated non-catalytic reduction procedure, this approach is high yielding and does not require purification steps and therefore could be conveniently used for the generation of compound libraries for drug discovery.
Titolo: | A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery |
Autori: | |
Data di pubblicazione: | 2015 |
Rivista: | |
Abstract: | An efficient and gram-scale continuous-flow protocol for the synthesis of the privileged structure 3,4-dihydro-5H-benzo[e][1,4]diazepin-5-one is reported. If compared to the traditional metal mediated non-catalytic reduction procedure, this approach is high yielding and does not require purification steps and therefore could be conveniently used for the generation of compound libraries for drug discovery. |
Handle: | http://hdl.handle.net/11386/4513057 |
Appare nelle tipologie: | 1.1.2 Articolo su rivista con ISSN |
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