Abstract A new approach for the production of microspheres from oil-in-water (O/W) emulsions using supercritical fluids is presented. The composition of the emulsions, consisting of 1-monoacylglycerol (1-MAG) and polyvinylalcohol (PVA) was first optimized, then supercritical assisted atomization (SAA) was applied to produce dried microparticles. The effect of different 1-MAG/PVA ratios and emulsion preparation method on size, stability, and morphology of microparticles was investigated using scanning electron microscopy, dynamic light scattering, differential scanning calorimetry and X-ray diffraction. The emulsion composition and emulsification method affected the sizes of microparticles and the smallest 1-MAG/PVA microparticles were obtained at lower 1-MAG (<30 mg/mL) and {PVA} (6 mg/mL) concentrations. Prepared 1-MAG/PVA microparticles had a spherical morphology with mean diameter ranging from 0.5 to 3 μm and a semi-crystalline structure. A maximum microparticle recovery of 55% was obtained.

Supercritical Assisted Atomization of emulsions for encapsulation of 1-monoacylglycerols in an hydrophilic carrier

ADAMI, RENATA
;
REVERCHON, Ernesto;
2015

Abstract

Abstract A new approach for the production of microspheres from oil-in-water (O/W) emulsions using supercritical fluids is presented. The composition of the emulsions, consisting of 1-monoacylglycerol (1-MAG) and polyvinylalcohol (PVA) was first optimized, then supercritical assisted atomization (SAA) was applied to produce dried microparticles. The effect of different 1-MAG/PVA ratios and emulsion preparation method on size, stability, and morphology of microparticles was investigated using scanning electron microscopy, dynamic light scattering, differential scanning calorimetry and X-ray diffraction. The emulsion composition and emulsification method affected the sizes of microparticles and the smallest 1-MAG/PVA microparticles were obtained at lower 1-MAG (<30 mg/mL) and {PVA} (6 mg/mL) concentrations. Prepared 1-MAG/PVA microparticles had a spherical morphology with mean diameter ranging from 0.5 to 3 μm and a semi-crystalline structure. A maximum microparticle recovery of 55% was obtained.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4570057
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