We report a new potent revisited version of a triazole-based inhibitor obtained by structure-based drug design on the human mPGES-1 crystal structure. Moreover, we disclosed the substitution with a halogen atom at position 5 as a new key factor influencing the biological activity on the mPGES-1 enzyme
Titolo: | Elucidating new structural features of the triazole scaffold for the development of mPGES-1 inhibitors |
Autori: | |
Data di pubblicazione: | 2015 |
Rivista: | |
Abstract: | We report a new potent revisited version of a triazole-based inhibitor obtained by structure-based drug design on the human mPGES-1 crystal structure. Moreover, we disclosed the substitution with a halogen atom at position 5 as a new key factor influencing the biological activity on the mPGES-1 enzyme |
Handle: | http://hdl.handle.net/11386/4651179 |
Appare nelle tipologie: | 1.1.1 Articolo su rivista con DOI |
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