Hsp90 C-terminal ligands are potential new anti-cancer drugs alternative to the more studied N-terminal inhibitors. Here we report the identification of a new dihydropyrimidinone binding the C-terminus, which is not structurally related to other well-known natural and nature-inspired inhibitors of this second druggable Hsp90 site.

Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold

STROCCHIA, MARIA;TERRACCIANO, Stefania;CHINI, MARIA GIOVANNA;DAL PIAZ, FABRIZIO;LEONE, ANTONIETTA;RICCIO, Raffaele;BRUNO, Ines;BIFULCO, Giuseppe
2015

Abstract

Hsp90 C-terminal ligands are potential new anti-cancer drugs alternative to the more studied N-terminal inhibitors. Here we report the identification of a new dihydropyrimidinone binding the C-terminus, which is not structurally related to other well-known natural and nature-inspired inhibitors of this second druggable Hsp90 site.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4651189
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