Two flavonoids, jaceosidin 7-O-β-D-glucopyranosyl-(1 →2)-β-D-glucopyranoside (1) and hispidulin 7-O-β-D-glucopyranosyl-(1 →2)-p-D-glucopyranoside (2), and one phenylpropanoid, 3,3'-dimethyl-lunariifolioside (3), along with 11 known compounds (4-14), were isolated from the aerial parts of Phlomis kurdica growing in Jordan. Structures of 1-3 were elucidated on the basis of spectroscopic data. These isolated compounds were assayed for their inhibitory activity against isoform 5 of human lactate dehydrogenase. Compound 4, luteolin 7-O-β-D-glucopyranoside, showed an IC50 value comparable to that of galloflavin, used as reference compound. Docking studies were carried out to hypothesize the interaction mode of compound 4 in the enzyme active site

Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase

DE TOMMASI, Nunziatina;
2015-01-01

Abstract

Two flavonoids, jaceosidin 7-O-β-D-glucopyranosyl-(1 →2)-β-D-glucopyranoside (1) and hispidulin 7-O-β-D-glucopyranosyl-(1 →2)-p-D-glucopyranoside (2), and one phenylpropanoid, 3,3'-dimethyl-lunariifolioside (3), along with 11 known compounds (4-14), were isolated from the aerial parts of Phlomis kurdica growing in Jordan. Structures of 1-3 were elucidated on the basis of spectroscopic data. These isolated compounds were assayed for their inhibitory activity against isoform 5 of human lactate dehydrogenase. Compound 4, luteolin 7-O-β-D-glucopyranoside, showed an IC50 value comparable to that of galloflavin, used as reference compound. Docking studies were carried out to hypothesize the interaction mode of compound 4 in the enzyme active site
2015
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4671585
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