Hsp90 C-terminal modulation represents an attractive strategy for the development of potent and safer antitumor compounds. Continuing our investigation on DHPM type inhibitors here we report a new set of potent C-terminal ligands which allowed us to identify the key structural features crucial for the biological activity.
Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors
TERRACCIANO, Stefania;CHINI, MARIA GIOVANNA;STROCCHIA, MARIA;FOGLIA, ANTONIO;VASSALLO, ANTONIO;SATURNINO, Carmela;RICCIO, Raffaele;BIFULCO, Giuseppe;BRUNO, Ines
2016-01-01
Abstract
Hsp90 C-terminal modulation represents an attractive strategy for the development of potent and safer antitumor compounds. Continuing our investigation on DHPM type inhibitors here we report a new set of potent C-terminal ligands which allowed us to identify the key structural features crucial for the biological activity.File in questo prodotto:
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