A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1-19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility.
Phakellistatins: An underwater unsolved puzzle
MELI, ALESSANDRA;TEDESCO, Consiglia;DELLA SALA, Giorgio;SCHETTINI, ROSARIA;DE RICCARDIS, Francesco;IZZO, Irene
2017-01-01
Abstract
A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1-19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility.File in questo prodotto:
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