A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1-19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility.

Phakellistatins: An underwater unsolved puzzle

MELI, ALESSANDRA;TEDESCO, Consiglia;DELLA SALA, Giorgio;SCHETTINI, ROSARIA;DE RICCARDIS, Francesco;IZZO, Irene
2017-01-01

Abstract

A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1-19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4682479
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