The first arylogous Michael reaction of 3-aryl phthalides has been developed. The reaction, promoted by catalytic amounts of KOH or K3PO4 and dibenzo-18-crown-6, affords the corresponding 3,3-disubstituted phthalides in good to high yields and as single diastereomers in nearly all studied cases.
Highly Diastereoselective Crown Ether Catalyzed Arylogous Michael Reaction of 3‑Aryl Phthalides
SICIGNANO, MARINA;DENTONI LITTA, ANTONELLA;SCHETTINI, ROSARIA;DE RICCARDIS, Francesco;PIERRI, GIOVANNI;TEDESCO, Consiglia;IZZO, Irene;DELLA SALA, Giorgio
2017-01-01
Abstract
The first arylogous Michael reaction of 3-aryl phthalides has been developed. The reaction, promoted by catalytic amounts of KOH or K3PO4 and dibenzo-18-crown-6, affords the corresponding 3,3-disubstituted phthalides in good to high yields and as single diastereomers in nearly all studied cases.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
