The first arylogous Michael reaction of 3-aryl phthalides has been developed. The reaction, promoted by catalytic amounts of KOH or K3PO4 and dibenzo-18-crown-6, affords the corresponding 3,3-disubstituted phthalides in good to high yields and as single diastereomers in nearly all studied cases.
Highly Diastereoselective Crown Ether Catalyzed Arylogous Michael Reaction of 3‑Aryl Phthalides
SICIGNANO, MARINA;DENTONI LITTA, ANTONELLA;SCHETTINI, ROSARIA;DE RICCARDIS, Francesco;PIERRI, GIOVANNI;TEDESCO, Consiglia;IZZO, Irene;DELLA SALA, Giorgio
2017
Abstract
The first arylogous Michael reaction of 3-aryl phthalides has been developed. The reaction, promoted by catalytic amounts of KOH or K3PO4 and dibenzo-18-crown-6, affords the corresponding 3,3-disubstituted phthalides in good to high yields and as single diastereomers in nearly all studied cases.File in questo prodotto:
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