The first arylogous Michael reaction of 3-aryl phthalides has been developed. The reaction, promoted by catalytic amounts of KOH or K3PO4 and dibenzo-18-crown-6, affords the corresponding 3,3-disubstituted phthalides in good to high yields and as single diastereomers in nearly all studied cases.

Highly Diastereoselective Crown Ether Catalyzed Arylogous Michael Reaction of 3‑Aryl Phthalides

SICIGNANO, MARINA;DENTONI LITTA, ANTONELLA;SCHETTINI, ROSARIA;DE RICCARDIS, Francesco;PIERRI, GIOVANNI;TEDESCO, Consiglia;IZZO, Irene;DELLA SALA, Giorgio
2017

Abstract

The first arylogous Michael reaction of 3-aryl phthalides has been developed. The reaction, promoted by catalytic amounts of KOH or K3PO4 and dibenzo-18-crown-6, affords the corresponding 3,3-disubstituted phthalides in good to high yields and as single diastereomers in nearly all studied cases.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/4691975
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