Supercritical antisolvent process phase equilibria in ternary systems: microparticles and nanoparticles precipitation

In this work, the jet break-up and the phases formation during the Supercritical Antisolvent (SAS) precipitation of different compounds were studied. Indeed, the formation of the different morphologies, such as expanded microparticles, microparticles, and nanoparticles can be obtained, varying the operating conditions. In order to observe some macroscopic aspects related to the process, a windowed SAS precipitator was used and the formation of one or more phases that influence the morphology of the powders was investigated. Two model compounds were precipitated, such as yttrium acetate and prednisolone.