BAG3 protein has emerged as a key regulator of important cellular processes and its expression is increased in some tumor types; however, despite its potential value for future chemotherapeutics, no selective BAG3 modulators have been yet reported. Here we report the 2,4-thiazolidinedione derivative 28 as the first BAG3 protein modulator.

Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics

Terracciano, Stefania
Project Administration
;
LAURO, GIANLUIGI;Russo, Alessandra;Vaccaro, Maria Carmela;VASSALLO, ANTONIO;De Marco, Margot;Rosati, Alessandra;Turco, Maria Caterina;Riccio, Raffaele;Bifulco, Giuseppe
;
Bruno, Ines
2018

Abstract

BAG3 protein has emerged as a key regulator of important cellular processes and its expression is increased in some tumor types; however, despite its potential value for future chemotherapeutics, no selective BAG3 modulators have been yet reported. Here we report the 2,4-thiazolidinedione derivative 28 as the first BAG3 protein modulator.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4716195
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