BAG3 protein has emerged as a key regulator of important cellular processes and its expression is increased in some tumor types; however, despite its potential value for future chemotherapeutics, no selective BAG3 modulators have been yet reported. Here we report the 2,4-thiazolidinedione derivative 28 as the first BAG3 protein modulator.
Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics
Terracciano, StefaniaProject Administration
;LAURO, GIANLUIGI;Russo, Alessandra;Vaccaro, Maria Carmela;VASSALLO, ANTONIO;De Marco, Margot;Rosati, Alessandra;Turco, Maria Caterina;Riccio, Raffaele;Bifulco, Giuseppe
;Bruno, Ines
2018-01-01
Abstract
BAG3 protein has emerged as a key regulator of important cellular processes and its expression is increased in some tumor types; however, despite its potential value for future chemotherapeutics, no selective BAG3 modulators have been yet reported. Here we report the 2,4-thiazolidinedione derivative 28 as the first BAG3 protein modulator.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
