Background: Frozen Section Analysis (FSA) Is Frequently Performed During Partial Nephrectomy (PN). We InvestiGate The Utility of Intraoperative Fsa By Evaluating Its Impact On Final Surgical Margin (SM) Status. Methods: Between January 1995 and December 2005, a Series of Patients Who Were Treated With Open Pn for Renal Cell Carcinoma Was Prospectively Analyzed. During Pn, Each Patient Underwent a Fsa On Renal Parenchyma Distal Margin. If Fsa Was Positive for Infiltration a Deeper Excision Was Performed Till Obtaining a Negative Fsa. Sm Outcome of The Fsa Was Compared With The Final Pathology Report. Recurrence-Free Survival (Rfs) and Cost Analysis On The Fsa Performed Were Analyzed. Results: a Total Number of 373 Patients Were Enrolled. Fsa Was Performed In All The Patients Considered for Pn. FifTeen Patients Had a Conversion to Radical Nephrectomy. Positive Sms At The Definitive Pathological Outcome Were Found In 36 Patients (9.6%). Fsa Was Positive In Eight Patients (2.1%). In That Eight Cases After a Deeper Excision The Definitive Pathological Outcome On Sm Was Still Positive In Two Cases. Fsa Revealed Just 14.3% of The Positive Sm. Patients With Positive Sm Had a Worse Follow Up Considering Rfs (P<0.05). Kaplan-Meier Analysis Revealed That Fsa Did Not ConsiderAbly Contribute to Prevent Recurrence (P=0.35). 1438 Euros Was The Mean Cost of Performing a Fsa During Pn. Conclusions: Fsa During Pn Does Not Reduce The Risk of Positive Sms. The Use of Fsa Has Also a Higher Cost Related to The Procedure.

Is there a clinical role for frozen section analysis during partial nephrectomy? a multicenter experience over 10 years

Verze P.;
2020

Abstract

Background: Frozen Section Analysis (FSA) Is Frequently Performed During Partial Nephrectomy (PN). We InvestiGate The Utility of Intraoperative Fsa By Evaluating Its Impact On Final Surgical Margin (SM) Status. Methods: Between January 1995 and December 2005, a Series of Patients Who Were Treated With Open Pn for Renal Cell Carcinoma Was Prospectively Analyzed. During Pn, Each Patient Underwent a Fsa On Renal Parenchyma Distal Margin. If Fsa Was Positive for Infiltration a Deeper Excision Was Performed Till Obtaining a Negative Fsa. Sm Outcome of The Fsa Was Compared With The Final Pathology Report. Recurrence-Free Survival (Rfs) and Cost Analysis On The Fsa Performed Were Analyzed. Results: a Total Number of 373 Patients Were Enrolled. Fsa Was Performed In All The Patients Considered for Pn. FifTeen Patients Had a Conversion to Radical Nephrectomy. Positive Sms At The Definitive Pathological Outcome Were Found In 36 Patients (9.6%). Fsa Was Positive In Eight Patients (2.1%). In That Eight Cases After a Deeper Excision The Definitive Pathological Outcome On Sm Was Still Positive In Two Cases. Fsa Revealed Just 14.3% of The Positive Sm. Patients With Positive Sm Had a Worse Follow Up Considering Rfs (P<0.05). Kaplan-Meier Analysis Revealed That Fsa Did Not ConsiderAbly Contribute to Prevent Recurrence (P=0.35). 1438 Euros Was The Mean Cost of Performing a Fsa During Pn. Conclusions: Fsa During Pn Does Not Reduce The Risk of Positive Sms. The Use of Fsa Has Also a Higher Cost Related to The Procedure.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4769593
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