The production of biocompatible nanocarriers, to induce a controlled, sustained and/or targeted drug delivery, is a fascinating nanotechnology challenge. Among the possible nanocarriers, niosomes are non-ionic compounds, with a lipophilic tail and a hydrophilic head, that can self-assemble in aqueous dispersions and can show a good stability over time. In this work, a continuous process, assisted by supercritical CO2, was used for the production of empty and theophylline loaded niosomes. The optimal results, in terms of niosomes nanometric dimension and stability verified up to 30 days, were obtained processing an ethanolic solution at a 90/10 Span® 80 to Tween® 80 ratio. A drug encapsulation efficiency of 85 % was measured when the supercritical process was carried out using a water flow rate of 1 mL/min. Theophylline release time was prolonged up to 5-folds, when this active compound was loaded in niosomes prepared at the largest surfactant to water ratio (100 mg/g).

Niosomes formation using a continuous supercritical CO2 assisted process

Baldino L.
;
Reverchon E.
2021

Abstract

The production of biocompatible nanocarriers, to induce a controlled, sustained and/or targeted drug delivery, is a fascinating nanotechnology challenge. Among the possible nanocarriers, niosomes are non-ionic compounds, with a lipophilic tail and a hydrophilic head, that can self-assemble in aqueous dispersions and can show a good stability over time. In this work, a continuous process, assisted by supercritical CO2, was used for the production of empty and theophylline loaded niosomes. The optimal results, in terms of niosomes nanometric dimension and stability verified up to 30 days, were obtained processing an ethanolic solution at a 90/10 Span® 80 to Tween® 80 ratio. A drug encapsulation efficiency of 85 % was measured when the supercritical process was carried out using a water flow rate of 1 mL/min. Theophylline release time was prolonged up to 5-folds, when this active compound was loaded in niosomes prepared at the largest surfactant to water ratio (100 mg/g).
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/4770992
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 5
social impact