Pyrrolizidine alkaloids (PAs) are plant-derived toxins with hepatotoxic and carcinogenic effects, increasingly detected in contaminated food products like spices and herbs, especially oregano. A sustainable UHPC-MS/MS method with SALLE extraction was validated for PA/PANO analysis, showing high sensitivity and efficiency. Analysis of 105 herb samples revealed 75% contamination, emphasizing the need for monitoring and regulation.
Determination of regulated pyrrolizidine alkaloids in aromatic herbs using liquid chromatography–tandem mass spectrometry combined with rapid-easy extraction
Rita Celano;Serena Rizzo;Anna Lisa Piccinelli;Simona Serio;Luca Campone;Luca Rastrelli
2023-01-01
Abstract
Pyrrolizidine alkaloids (PAs) are plant-derived toxins with hepatotoxic and carcinogenic effects, increasingly detected in contaminated food products like spices and herbs, especially oregano. A sustainable UHPC-MS/MS method with SALLE extraction was validated for PA/PANO analysis, showing high sensitivity and efficiency. Analysis of 105 herb samples revealed 75% contamination, emphasizing the need for monitoring and regulation.File in questo prodotto:
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