In this work, cannabidiol (CBD) nanoparticles contained in polyvinylpyrrolidone (PVP) microparticles (nano-in-micro system) were produced by supercritical CO2 assisted atomization (SAA) with the aim of improving CBD bioavailability. The experiments were performed by changing the total concentration of solute PVP + CBD and CBD/PVP mass ratio (R) to understand the effect of these parameters on CBD nanoparticle mean size, measured by a dynamic light scattering operating in a periodic manner. Nanoparticles as small as 33 nm were obtained, protected in PVP microparticles. CBD release tests were carried out to verify the increase in the solubilization rate of CBD nanoparticles: pure CBD powder was completely dissolved in about 240 min; whereas CBD 55 nm nanoparticles were completely released in 20 min.
Production of cannabidiol nanoparticles loaded in polyvinylpyrrolidone microparticles by supercritical CO2 assisted atomization and dissolution enhancement effect
Baldino, Lucia;Sarnelli, Sonia;Palazzo, Ida;Scognamiglio, Mariarosa;Reverchon, Ernesto
2025
Abstract
In this work, cannabidiol (CBD) nanoparticles contained in polyvinylpyrrolidone (PVP) microparticles (nano-in-micro system) were produced by supercritical CO2 assisted atomization (SAA) with the aim of improving CBD bioavailability. The experiments were performed by changing the total concentration of solute PVP + CBD and CBD/PVP mass ratio (R) to understand the effect of these parameters on CBD nanoparticle mean size, measured by a dynamic light scattering operating in a periodic manner. Nanoparticles as small as 33 nm were obtained, protected in PVP microparticles. CBD release tests were carried out to verify the increase in the solubilization rate of CBD nanoparticles: pure CBD powder was completely dissolved in about 240 min; whereas CBD 55 nm nanoparticles were completely released in 20 min.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
