S140 P. Iovino 1, G. Bilancio 2, R. Tortora1, C. Bucci 1, A. Pascariello 1 , M. Siniscalchi 1 , C. Ciacci ∗ ,1 1Università Federico II, Napoli; 2Nefrologia Seconda Università, Napoli Background and aim: Head-down bed rest condition (HDBR) is a microgravity model simulating condition of space flight. Aim of the study was to evaluate gastrointestinal function during long lasting HDBR. Material and methods: The study was performed in 2008 and sponsored by the OSMA (OSteporosis and Muscular Atrophy) grant of the Italian Space Agency in the Valdoltra Hospital, Ankaran (Slovenia). Ten healthy male volunteers were subjected to a 35-day 6° head-down tilt and balanced traction bed rest (HDBR). All participants received an energy-controlled diet. Antropometry, food and water intake were recorded daily. Assessment of general health by Goldberg’s general health Questionnaire and Zung depression mood scale were administrated before (Wk 0) and after HDBR (Wk 6). Esophageal and gastric symptoms were investigated weekly by symptoms questionnaires on frequency and intensity of oesophageal, gastric and bowel symptoms (on adjectival scale: Bristol stool form scale, ease of passage adjectival scale and sense of complete evacuation). Results: Pre and post HDBR no variation of general health perception was found. HDBR significantly reduces body mass index and the gastric cumulative perception score, but not esophageal cumulative perception score (F(4,36)=32.870, p<0.001 and F(4,36)=3.568, p<0.05 respectively). In particular the lean mass, but also fat mass progressively reduced over time (F(4,36)= 22.534, p<0.001 and F (4,36)= 3.438, p<0.05 respectively). The gastric cumulative perception score is strongly correlated to body weight. (r=0.899, p<0.05). HDBR significantly increases the sensation of flatulence (F(2.1,19.5)=4.397 p<0.05) and reduced the stool frequency (F(1.9,17.2)=4.043, p<0.05). A strong correlation was found between the calculated mean sensation of flatulence and stool frequency (r= -0.972, p=0.006). Conclusions: Gastric symptoms tended to reduce their intensityfrequency over time during HDBR. This seems to be related to body weight decrease, which is mainly due to lean mass loss. Measures should be taken to avoid constipation and perception of bowel distension. An hypothesis is made that controlled and scheduled food intake, and/or water intake increase may play a role in reducing gastrointestinal symptoms during HDBR. # M. Functional disorders 2. IBS

Gastrointestinal function in simulated space flight microgravity

IOVINO, Paola;BILANCIO, GIANCARLO;BUCCI, CRISTINA;Siniscalchi M;CIACCI, Carolina
2009-01-01

Abstract

S140 P. Iovino 1, G. Bilancio 2, R. Tortora1, C. Bucci 1, A. Pascariello 1 , M. Siniscalchi 1 , C. Ciacci ∗ ,1 1Università Federico II, Napoli; 2Nefrologia Seconda Università, Napoli Background and aim: Head-down bed rest condition (HDBR) is a microgravity model simulating condition of space flight. Aim of the study was to evaluate gastrointestinal function during long lasting HDBR. Material and methods: The study was performed in 2008 and sponsored by the OSMA (OSteporosis and Muscular Atrophy) grant of the Italian Space Agency in the Valdoltra Hospital, Ankaran (Slovenia). Ten healthy male volunteers were subjected to a 35-day 6° head-down tilt and balanced traction bed rest (HDBR). All participants received an energy-controlled diet. Antropometry, food and water intake were recorded daily. Assessment of general health by Goldberg’s general health Questionnaire and Zung depression mood scale were administrated before (Wk 0) and after HDBR (Wk 6). Esophageal and gastric symptoms were investigated weekly by symptoms questionnaires on frequency and intensity of oesophageal, gastric and bowel symptoms (on adjectival scale: Bristol stool form scale, ease of passage adjectival scale and sense of complete evacuation). Results: Pre and post HDBR no variation of general health perception was found. HDBR significantly reduces body mass index and the gastric cumulative perception score, but not esophageal cumulative perception score (F(4,36)=32.870, p<0.001 and F(4,36)=3.568, p<0.05 respectively). In particular the lean mass, but also fat mass progressively reduced over time (F(4,36)= 22.534, p<0.001 and F (4,36)= 3.438, p<0.05 respectively). The gastric cumulative perception score is strongly correlated to body weight. (r=0.899, p<0.05). HDBR significantly increases the sensation of flatulence (F(2.1,19.5)=4.397 p<0.05) and reduced the stool frequency (F(1.9,17.2)=4.043, p<0.05). A strong correlation was found between the calculated mean sensation of flatulence and stool frequency (r= -0.972, p=0.006). Conclusions: Gastric symptoms tended to reduce their intensityfrequency over time during HDBR. This seems to be related to body weight decrease, which is mainly due to lean mass loss. Measures should be taken to avoid constipation and perception of bowel distension. An hypothesis is made that controlled and scheduled food intake, and/or water intake increase may play a role in reducing gastrointestinal symptoms during HDBR. # M. Functional disorders 2. IBS
2009
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/3035870
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