PEPE, Stefano
 Distribuzione geografica
Continente #
NA - Nord America 14.029
AS - Asia 7.340
EU - Europa 4.348
SA - Sud America 746
Continente sconosciuto - Info sul continente non disponibili 321
AF - Africa 120
OC - Oceania 15
Totale 26.919
Nazione #
US - Stati Uniti d'America 13.835
HK - Hong Kong 2.596
SG - Singapore 2.074
IT - Italia 1.648
CN - Cina 1.190
UA - Ucraina 769
VN - Vietnam 603
BR - Brasile 594
DE - Germania 466
RU - Federazione Russa 336
IE - Irlanda 273
FI - Finlandia 238
FR - Francia 218
KR - Corea 185
TR - Turchia 172
IN - India 126
CA - Canada 100
GB - Regno Unito 98
SE - Svezia 96
BD - Bangladesh 91
AR - Argentina 59
JP - Giappone 56
IQ - Iraq 46
AT - Austria 43
NL - Olanda 41
MX - Messico 38
ID - Indonesia 37
PK - Pakistan 32
EU - Europa 30
ES - Italia 26
ZA - Sudafrica 24
UZ - Uzbekistan 23
CO - Colombia 22
CZ - Repubblica Ceca 22
PL - Polonia 22
EC - Ecuador 21
JO - Giordania 20
MA - Marocco 19
TN - Tunisia 18
CL - Cile 14
IL - Israele 14
VE - Venezuela 14
CR - Costa Rica 12
DZ - Algeria 12
JM - Giamaica 12
KE - Kenya 11
SA - Arabia Saudita 10
AU - Australia 9
MY - Malesia 8
PE - Perù 8
PH - Filippine 7
PY - Paraguay 7
RO - Romania 7
AL - Albania 6
EG - Egitto 6
KG - Kirghizistan 6
AE - Emirati Arabi Uniti 5
AZ - Azerbaigian 5
BG - Bulgaria 5
CH - Svizzera 5
OM - Oman 5
XK - ???statistics.table.value.countryCode.XK??? 5
GT - Guatemala 4
IS - Islanda 4
NG - Nigeria 4
PA - Panama 4
TT - Trinidad e Tobago 4
BO - Bolivia 3
DO - Repubblica Dominicana 3
ET - Etiopia 3
GR - Grecia 3
HN - Honduras 3
LB - Libano 3
LT - Lituania 3
MD - Moldavia 3
NI - Nicaragua 3
NO - Norvegia 3
NP - Nepal 3
NZ - Nuova Zelanda 3
PR - Porto Rico 3
SN - Senegal 3
SY - Repubblica araba siriana 3
UY - Uruguay 3
AO - Angola 2
BF - Burkina Faso 2
BH - Bahrain 2
BS - Bahamas 2
DK - Danimarca 2
EE - Estonia 2
IR - Iran 2
KH - Cambogia 2
KZ - Kazakistan 2
MK - Macedonia 2
MN - Mongolia 2
PT - Portogallo 2
SC - Seychelles 2
SV - El Salvador 2
TH - Thailandia 2
TW - Taiwan 2
ZM - Zambia 2
Totale 26.602
Città #
Ann Arbor 2.852
Hong Kong 2.591
Woodbridge 1.236
Singapore 1.174
Wilmington 1.083
San Jose 940
Jacksonville 924
Houston 919
Chandler 794
Princeton 663
Milan 631
Ashburn 592
Dallas 572
Beijing 381
Council Bluffs 356
Dong Ket 290
Dublin 268
Lauterbourg 183
Munich 176
Andover 172
The Dalles 168
Nanjing 150
Izmir 145
Boardman 125
Pellezzano 125
Rome 125
Santa Clara 124
Naples 113
Ho Chi Minh City 111
Mestre 107
Los Angeles 98
Moscow 87
New York 79
Hanoi 77
Düsseldorf 67
São Paulo 59
Fairfield 55
Memphis 50
Nanchang 50
Tokyo 50
Helsinki 47
Salerno 46
Shenyang 46
Chicago 44
Hebei 44
Figino 41
Washington 39
Changsha 38
Jiaxing 37
Orem 33
Brooklyn 32
Pune 32
Turin 31
Nuremberg 29
Columbus 28
Turku 28
Falls Church 27
Tianjin 26
Vienna 26
San Francisco 25
Frankfurt am Main 24
Montreal 23
Norwalk 23
Seattle 23
Tashkent 21
Brasília 20
London 20
Warsaw 20
Amman 19
Chennai 19
Phoenix 19
Toronto 19
Denver 18
Amsterdam 17
Baghdad 17
Brno 17
Mexico City 17
Venezia 17
Atlanta 16
Boston 16
Cambridge 16
Rio de Janeiro 16
Da Nang 15
Haiphong 15
Redwood City 15
Guangzhou 14
Shanghai 14
Biên Hòa 13
Bologna 13
Fisciano 13
Mumbai 13
Paris 13
San Diego 13
Manchester 12
Ottawa 12
Quito 12
Stockholm 12
Belo Horizonte 11
Buffalo 11
Philadelphia 11
Totale 20.110
Nome #
Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype 609
Prior Anti-Angiogenic TKI-Based Treatment as Potential Predisposing Factor to Nivolumab-Mediated Recurrent Thyroid Disorder Adverse Events in mRCC Patients: A Case Series 540
Bispecific Antibodies: A Novel Approach for the Treatment of Solid Tumors 517
Differential sensitivity to non-MHC-restricted rIL-2 activated lymphocyte killing of human mammary epithelial MCF-10A cells overexpressing oncogenes or PKA subunits. 369
Abstract 3132: Single nucleotide polymorphisms (SNPs) in PD-L1 as predictive biomarkers for checkpoint inhibitor based-immunotherapy in caucasian patients with advanced NSCLC 338
Measurement of neovascularization is an independent prognosticator of survival in node-negative breast cancer patients with long-term follow-up 310
Synergistic antitumor activity of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and IFN-A in head and neck cancer cells in vitro and in vivo 300
The role of immunotherapy in solid tumors: report from the Campania Society of Oncology Immunotherapy (SCITO) meeting, Naples 2014. 296
Evaluation of Potential Predictive Biomarkers for Defining Brain Radiotherapy Efficacy in Non-Small Cell Lung Cancer Patients with Brain Metastases: A Case Report and a Narrative Review 259
Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications. 223
Overexpression of wild-type p53 ovverrides the mitogenic effect of the RIa subunit of protein kinase A in human breast cells. 207
rs822336 as a predictive biomarker for anti-PD-1/PD-L1 immunotherapy in advanced NSCLC: Unraveling molecular mechanisms 202
Additive effects of c-erbB-2, c-Ha-ras, and transforming growth factor-a genes on in vitro transformation of human mammary epithelial cells. 193
A genotyping/phenotyping approach with careful clinical monitoring to manage the fluoropyrimidines-based therapy: Clinical cases and systematic review of the literature 190
Nuclear DNA content-derived parameters correlated with heterogeneous expression of p53 and bcl-2 proteins in clear cell renal carcinomas. 188
A phase I-II trial of gefitinib (IRESSA) and radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck (SCCHN) 187
Adjuvant treatment of diabetic foot 183
Phase I clinical study with 8-Chloro-cAMP and evaluation of immunological effects in cancer patients. 182
5-Aza-2'-Deoxycitidine induces growth-inhibition and up-regulation of epidermal-growth factor receptor on human epithelial cancer-cells 182
ADDITION OF ERLOTINIB TO FLUROPYRIMIDINE-OXALIPLATIN-BASED CHEMOTHERAPY WITH OR WITHOUT BEVACIZUMAB: TWO SEQUENTIAL PHASE I TRIALS. 179
A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FLFOX-4) as first-line treatment of advanced gastric cancer patients. 177
Reversal of adriamycin resistance by recombinant alpha-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells. 171
Anti-sense oligonucleotides directed against EGF-related growth factors enhance anti-proliferative effect of conventional anti-tumor drugs in human colon-cancer cells. 166
8-Chloro-cAMP enhances the growth inhibitory effect of cytotoxic drugs in human colon cancer cells 166
Poly(ADPR)polymerase-1 signalling of the DNA damage induced by DNA topoisomerase I poison in D54p53wt and U251p53mut glioblastoma cell lines. 166
Procoagulant and fibrinolytic activity of human ovarian carcinoma cells in culture. 166
Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective EGFR-tyrosine kinase inhibitor ZD1839 (‘Iressa’) 164
Activity and safety of pegylated liposomal doxorubicin, 5-fluorouracil and folinic acid in inoperable hepatocellular carcinoma: a phase II study. 163
A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patients. 163
Regulation of the expression of Fc-epsilon-R in the human monocyte like cell line U937 by TPA and IgE. 163
8-Cl-cAMP in differentiation therapy: The reversal and suppression of malignancy targeting the intracellular transducing proteins of cAMP. 159
Adjuvant Treatment for Locally Advanced Rectal Cancer Patients After Preoperative Chemoradiotherapy: When, and for Whom? 158
Abstract 4017: Anti-tumor activity of a BRAF inhibitor and IFNα combination in BRAF mutant melanoma 158
TSH-regulated growth and cell cycle distribution of thyroid cells involve type I isozyme of cAMP-dependent protein kinase 157
Tumori Eredo-Familiari 157
Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27. 156
Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed. 156
Down-regulation of RI alpha subunit of cAMP-dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c-Ha-ras and c-erbB-2 proto-oncogenes. 156
Antitumor activity of BRAF inhibitor and IFN×alpha; Combination in BRAF-mutant melanoma 156
Synergistic anti-tumour effect of raltitrexed and 5-fluorouracil plus folinic acid combination in human cancer cells. 155
Recombinant IFN-alfa 2b treatment activates poly (ADPR) polymerase-1 (PARP-1) in KB cancer cells. 155
NM23 gene expression correlates with cell growth rate and S-phase. 155
Expression of teratocarcinoma-derived growth factor-1 (TDGF-1) in testis germ cell tumors and its effects on growth and differentiation of embryonal carcinoma cell line NTERA2/D1. 151
Altre Neoplasie 151
A specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer 151
Enhanced Expression of CD47 Is Associated With Off-Target Resistance to Tyrosine Kinase Inhibitor Gefitinib in NSCLC 151
A phase I/II trial of gefitinib and radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck. 150
Analysis of Differential miRNA Expression in Primary Tumor and Stroma of Colorectal Cancer Patients 150
DNA index of ovarian carcinomas from 56 different patients: in vivo, in vitro studies. 148
Farsi promotori di salute: “Safe Sun Coast” 148
Non lymphomatous clonal B-Cell populations in enlarged lymph nodes in acquired immunodeficiency syndrome. 147
Sequence-dependent, synergistic antiproliferative and proapoptotic effects of the combination of cytotoxic drugs and enzastaurin, a protein kinase C beta inhibitor, in non-small cell lung cancer cells. 146
rs10204525 binding to miR-4717-3p modulates PD-1 expression and predicts the development of immune-related adverse events in advanced cancer patients treated with anti-PD-1/PD-L1 therapy 145
Predictive factors of response to neoadjuvant chemoradiotherapy in rectal cancer patirnts. 145
Loss of thyrotropin regulation and trasforming growth factor beta-induced growth arrest in erbB-2 overexpressing rat thyroid cells. 144
The expression of proliferating cell nuclear antigen in paraffin sections of peripheral, node-negative non-small cell lung cancer. 144
TGFb inhibits rat thyroid cell proliferation without alterations in the expression of THS-induced cell cycle-related genes. Vol :pp , 143
Type-I isoform of PKA is involved in the control of cell proliferation and oncogene transformation of human mammary epithelial cells.Therapeutic implications 143
Oral antisense targeting protein kinase A type I causes antitumor and apoptotic effect in human cancer cells in vitro and in vivo and has cooperative activity in combination with antisense bcl-2. 142
Critical role of both p27kip1 and p21cip1/waf1 in the antiproliferative effect of ZD1839 (‘Iressa’), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells. 141
DNA-flow cytometry (ploidy and S-phase fraction) as prognostic factor in a retrospectine series of 515 primary breast cancer. 141
A Specific miRNA Signature Correlates with Complete Pathological Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer. 141
Bevacizumab maintenance in metastatic colorectal cancer: How long?. 141
Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: a phase II study. 140
Reduction of RIAlpha subunit of cAMP-dependent Protein-Kinase expression induces growth-inhibition of human mammary epithelial-cells transformed by TGF-Alha, C-HA-RAS, and C-ErbB2 genes. 140
Growth inhibition of tumor cells by epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is associated with upregulation of p27 and p21 cyclin-dependent kinase inhibitors. 140
Abstract 3703: PDGFRα up-regulation mediated by Sonic Hedgehog Pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation 140
Growth arrest, apoptosis and potentiation of 5-fluorouracil and Raltitrexed cytotoxic effect induced by histone deacetylase inhibitor SAHA in colorectal cancer cells. 139
Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells. 138
Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting Protein Kinase A in combination with docetaxel and anti-EGFR-Receptor antibody on human breast cancer cell growth. 138
21st ISoP Annual Meeting “A New Era of Pharmacovigilance: Challenges and Opportunities” 20–23 September 2022 Verona, Italy 137
Cell growth-inhibition and cell cycle perturbations induced by a new synthetic iminoquinone, 5H-pyridophenoxazin-5-one, in human breast carcinoma cell lines. 137
Inhibition of NF-kB activity potentiates ionizing radiation and cisplatin induced cell killing of anaplastic thyroid carcinoma cells AACR Meeting Abstracts, Apr 2006; 2006: 1038. 136
TESI DI DOTTORATO: Hereditary and familial breast and ovarian cancer: spectrum of related tumors. CANDIDATO: M.Pensabene. RELATORE: S.Pepe 134
Measurement of neovascularization is an independent prognosticator of survival in node-negative breast cancer patients with long-lerm follow-up. 133
Enzastaurin inhibits tumors sensitive and resistant to anti-EGFR drugs 133
Phase I-II study of sequential combination of XELOX and bevacizumab plus erlotinib (XELOX-TARAV) in first line colorectal patients:Run in phase I part 133
Theophylline-induced apoptosis is paralleled by protein kinase A-dependent tissue transglutaminase activation in cancer cells. 133
PRECLINICAL AND PHASE I STUDY OF OXALIPLATIN AND TOPOTECAN IN COMBINATION IN HUMAN CANCER. 131
Suppression of malignancy targeting the intracellular signal transducing proteins of cAMP: the use of site selective cAMP analogs, antisense strategy, and gene-transfer. 130
Synerglstic antltumor effect by novel modified oligonucleotides targeting PKAI combined with cytotoxic drugs or monoclonal antibodies. 130
Overexpression of the RIα subunit of Protein Kinase A confers hypersensitivity to topoisomerase II inhibitors and 8-Chloro-cyclic Adenosine 3′,5′-Monophosphate in chinese hamster ovary cells. 129
Cell ploidy in 19 Wilms tumors by flow-cytometry of cell suspensions prepared from paraffina embedded sections. 129
Synergistic inhibition of growth and induction of apoptosis by 8-chloro-cAMP and paclitaxel or cisplatin in human cancer cells. 128
POLY(ADENOSINE DIPHOSPHATE-RIBOSE) POLYMERASE 1 EXPRESSION IN MALIGNANT MELANOMAS FROM PHOTOEXPOSED AREAS OF THE HEAD AND NECK REGION. 128
EGF-R tyrosyne kinase as new target in melanoma treatment; Synergistic effect of IFN alpha in combination with ZD1839 )Iressa) , an EGFR tyrosine kinase inhibitor. 128
P53 expression in non-small-cell lung-cancer. Clinical and biological correlations. 127
Cooperative effect of 8-Cl-cAMP and rhGM-CSF on the differentiation of HL-60 human leukemia-cells. 127
The cancer spectrum related to hereditary and familial breast and ovarian cancers 126
EGF activates an inducible survival response via the RAS -> Erk-1/2 pathway to counteract interferon-alfa-mediated apoptosis in epidermoid cancer cells. 126
Blast cells DNA content in childhood leukemias. 126
IgE receptors. 125
KRAS mutations in advanced non-small cell lung cancer: From biology to novel therapeutic strategies 125
Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment. 124
Phorbol-12-myristate-13-acetate (PMA) induces resistance of human melanoma cells to NK and LAK-mediated cytotoxicity. 124
Multidisciplinary Approach to Patient with Malignant Melanoma 124
Interferon-alpha induces apoptosis in human KB cells through a stress-dependent mitogen activated protein kinase pathway death is antagonized by epidermal growth factor. 123
Diagnostic utility of BRAFV600E mutation testing in thyroid nodules in elderly patients 122
Molecules and mechanisms to overcome oxidative stress inducing cardiovascular disease in cancer patients 122
Two mutations of BRCA2 gene at exon and splicing site in a woman who underwent oncogenetic counseling 121
Totale 17.086
Categoria #
all - tutte 80.990
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 80.990


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.177 0 0 3 35 30 39 15 54 189 161 141 510
2022/20231.923 190 91 53 246 271 420 2 169 357 10 74 40
2023/20241.135 80 136 66 27 67 142 276 61 28 39 47 166
2024/20252.370 78 33 52 94 147 364 392 242 317 102 243 306
2025/20269.864 572 1.670 1.421 380 953 565 1.400 278 593 822 230 980
2026/2027827 406 300 121 0 0 0 0 0 0 0 0 0
Totale 26.919