PEPE, Stefano
 Distribuzione geografica
Continente #
NA - Nord America 11.255
AS - Asia 5.015
EU - Europa 2.905
SA - Sud America 435
AF - Africa 43
Continente sconosciuto - Info sul continente non disponibili 33
OC - Oceania 11
Totale 19.697
Nazione #
US - Stati Uniti d'America 11.181
HK - Hong Kong 2.498
CN - Cina 930
UA - Ucraina 764
SG - Singapore 753
IT - Italia 577
DE - Germania 435
BR - Brasile 401
RU - Federazione Russa 326
VN - Vietnam 326
IE - Irlanda 266
FI - Finlandia 232
KR - Corea 179
TR - Turchia 152
SE - Svezia 91
IN - India 62
GB - Regno Unito 54
AT - Austria 41
CA - Canada 41
EU - Europa 30
CZ - Repubblica Ceca 22
FR - Francia 21
JP - Giappone 20
ES - Italia 17
NL - Olanda 16
BD - Bangladesh 15
IQ - Iraq 15
MX - Messico 15
PL - Polonia 13
AR - Argentina 12
JO - Giordania 10
ID - Indonesia 9
PK - Pakistan 8
MA - Marocco 7
UZ - Uzbekistan 7
CR - Costa Rica 6
DZ - Algeria 6
IL - Israele 6
TN - Tunisia 6
AU - Australia 5
EC - Ecuador 5
RO - Romania 5
ZA - Sudafrica 5
AE - Emirati Arabi Uniti 4
AL - Albania 4
BG - Bulgaria 4
CH - Svizzera 4
CO - Colombia 4
VE - Venezuela 4
KG - Kirghizistan 3
NP - Nepal 3
NZ - Nuova Zelanda 3
PA - Panama 3
PY - Paraguay 3
AZ - Azerbaigian 2
BF - Burkina Faso 2
CL - Cile 2
DK - Danimarca 2
EG - Egitto 2
GR - Grecia 2
GT - Guatemala 2
IR - Iran 2
JM - Giamaica 2
LT - Lituania 2
MY - Malesia 2
NO - Norvegia 2
PE - Perù 2
SA - Arabia Saudita 2
SN - Senegal 2
XK - ???statistics.table.value.countryCode.XK??? 2
ZM - Zambia 2
AG - Antigua e Barbuda 1
BH - Bahrain 1
BJ - Benin 1
BS - Bahamas 1
BW - Botswana 1
BY - Bielorussia 1
CM - Camerun 1
CV - Capo Verde 1
CW - ???statistics.table.value.countryCode.CW??? 1
DO - Repubblica Dominicana 1
EE - Estonia 1
GF - Guiana Francese 1
KE - Kenya 1
KH - Cambogia 1
KI - Kiribati 1
LB - Libano 1
MD - Moldavia 1
MK - Macedonia 1
ML - Mali 1
MM - Myanmar 1
MN - Mongolia 1
MU - Mauritius 1
MZ - Mozambico 1
NA - Namibia 1
NG - Nigeria 1
NR - Nauru 1
PR - Porto Rico 1
PT - Portogallo 1
RW - Ruanda 1
Totale 19.692
Città #
Ann Arbor 2.852
Hong Kong 2.498
Woodbridge 1.235
Wilmington 1.081
Jacksonville 921
Houston 904
Chandler 793
Princeton 663
Dallas 556
Beijing 299
Ashburn 290
Dong Ket 290
Dublin 262
Singapore 261
Munich 176
Andover 172
Nanjing 150
Izmir 145
Pellezzano 125
Boardman 124
Mestre 107
Moscow 87
Düsseldorf 67
Fairfield 55
Naples 54
Nanchang 50
Los Angeles 49
Shenyang 46
Hebei 44
Salerno 43
Helsinki 42
New York 41
Jiaxing 37
Changsha 35
Washington 35
São Paulo 34
Pune 31
Nuremberg 29
The Dalles 29
Turku 27
Falls Church 26
Tianjin 26
Columbus 24
Vienna 24
Brooklyn 23
Santa Clara 23
Norwalk 22
San Francisco 22
Chicago 21
Seattle 21
Brno 17
Tokyo 17
Venezia 17
Cambridge 16
London 16
Redwood City 15
Ho Chi Minh City 14
Warsaw 13
Guangzhou 12
Milan 12
Ottawa 12
Paris 12
San Diego 12
Brasília 11
Montreal 11
Amman 10
Boston 10
Chennai 10
Rome 10
Tappahannock 10
Seoul 9
Shanghai 9
Baghdad 8
Dearborn 8
Hanoi 8
Rio de Janeiro 8
Atlanta 7
Belo Horizonte 7
Charlotte 7
Indiana 7
Napoli 7
Sarno 7
Stockholm 7
Tashkent 7
Amsterdam 6
Castellammare di Stabia 6
Jinan 6
Jyväskylä 6
Porto Alegre 6
Bologna 5
Council Bluffs 5
Denver 5
Fisciano 5
Hangzhou 5
Mercato San Severino 5
Mountain View 5
Phoenix 5
Rutigliano 5
San Jose 5
Shijiazhuang 5
Totale 15.419
Nome #
Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype 585
Prior Anti-Angiogenic TKI-Based Treatment as Potential Predisposing Factor to Nivolumab-Mediated Recurrent Thyroid Disorder Adverse Events in mRCC Patients: A Case Series 483
Bispecific Antibodies: A Novel Approach for the Treatment of Solid Tumors 469
Differential sensitivity to non-MHC-restricted rIL-2 activated lymphocyte killing of human mammary epithelial MCF-10A cells overexpressing oncogenes or PKA subunits. 344
Synergistic antitumor activity of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and IFN-A in head and neck cancer cells in vitro and in vivo 274
Measurement of neovascularization is an independent prognosticator of survival in node-negative breast cancer patients with long-term follow-up 267
Abstract 3132: Single nucleotide polymorphisms (SNPs) in PD-L1 as predictive biomarkers for checkpoint inhibitor based-immunotherapy in caucasian patients with advanced NSCLC 260
The role of immunotherapy in solid tumors: report from the Campania Society of Oncology Immunotherapy (SCITO) meeting, Naples 2014. 258
Evaluation of Potential Predictive Biomarkers for Defining Brain Radiotherapy Efficacy in Non-Small Cell Lung Cancer Patients with Brain Metastases: A Case Report and a Narrative Review 202
Overexpression of wild-type p53 ovverrides the mitogenic effect of the RIa subunit of protein kinase A in human breast cells. 182
Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications. 180
Nuclear DNA content-derived parameters correlated with heterogeneous expression of p53 and bcl-2 proteins in clear cell renal carcinomas. 158
Phase I clinical study with 8-Chloro-cAMP and evaluation of immunological effects in cancer patients. 157
A phase I-II trial of gefitinib (IRESSA) and radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck (SCCHN) 145
Anti-sense oligonucleotides directed against EGF-related growth factors enhance anti-proliferative effect of conventional anti-tumor drugs in human colon-cancer cells. 142
Procoagulant and fibrinolytic activity of human ovarian carcinoma cells in culture. 142
Additive effects of c-erbB-2, c-Ha-ras, and transforming growth factor-a genes on in vitro transformation of human mammary epithelial cells. 139
Adjuvant treatment of diabetic foot 138
rs822336 as a predictive biomarker for anti-PD-1/PD-L1 immunotherapy in advanced NSCLC: Unraveling molecular mechanisms 137
ADDITION OF ERLOTINIB TO FLUROPYRIMIDINE-OXALIPLATIN-BASED CHEMOTHERAPY WITH OR WITHOUT BEVACIZUMAB: TWO SEQUENTIAL PHASE I TRIALS. 137
Reversal of adriamycin resistance by recombinant alpha-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells. 136
Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed. 136
Poly(ADPR)polymerase-1 signalling of the DNA damage induced by DNA topoisomerase I poison in D54p53wt and U251p53mut glioblastoma cell lines. 136
5-Aza-2'-Deoxycitidine induces growth-inhibition and up-regulation of epidermal-growth factor receptor on human epithelial cancer-cells 136
Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective EGFR-tyrosine kinase inhibitor ZD1839 (‘Iressa’) 134
A genotyping/phenotyping approach with careful clinical monitoring to manage the fluoropyrimidines-based therapy: Clinical cases and systematic review of the literature 134
A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FLFOX-4) as first-line treatment of advanced gastric cancer patients. 133
Recombinant IFN-alfa 2b treatment activates poly (ADPR) polymerase-1 (PARP-1) in KB cancer cells. 132
Tumori Eredo-Familiari 132
Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27. 131
NM23 gene expression correlates with cell growth rate and S-phase. 131
Regulation of the expression of Fc-epsilon-R in the human monocyte like cell line U937 by TPA and IgE. 127
8-Cl-cAMP in differentiation therapy: The reversal and suppression of malignancy targeting the intracellular transducing proteins of cAMP. 125
TSH-regulated growth and cell cycle distribution of thyroid cells involve type I isozyme of cAMP-dependent protein kinase 124
Adjuvant Treatment for Locally Advanced Rectal Cancer Patients After Preoperative Chemoradiotherapy: When, and for Whom? 124
Synergistic anti-tumour effect of raltitrexed and 5-fluorouracil plus folinic acid combination in human cancer cells. 122
Down-regulation of RI alpha subunit of cAMP-dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c-Ha-ras and c-erbB-2 proto-oncogenes. 122
Activity and safety of pegylated liposomal doxorubicin, 5-fluorouracil and folinic acid in inoperable hepatocellular carcinoma: a phase II study. 121
Sequence-dependent, synergistic antiproliferative and proapoptotic effects of the combination of cytotoxic drugs and enzastaurin, a protein kinase C beta inhibitor, in non-small cell lung cancer cells. 118
Analysis of Differential miRNA Expression in Primary Tumor and Stroma of Colorectal Cancer Patients 118
Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting Protein Kinase A in combination with docetaxel and anti-EGFR-Receptor antibody on human breast cancer cell growth. 117
Antitumor activity of BRAF inhibitor and IFN×alpha; Combination in BRAF-mutant melanoma 117
Non lymphomatous clonal B-Cell populations in enlarged lymph nodes in acquired immunodeficiency syndrome. 117
A phase I/II trial of gefitinib and radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck. 115
Loss of thyrotropin regulation and trasforming growth factor beta-induced growth arrest in erbB-2 overexpressing rat thyroid cells. 114
A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patients. 114
Reduction of RIAlpha subunit of cAMP-dependent Protein-Kinase expression induces growth-inhibition of human mammary epithelial-cells transformed by TGF-Alha, C-HA-RAS, and C-ErbB2 genes. 113
Oral antisense targeting protein kinase A type I causes antitumor and apoptotic effect in human cancer cells in vitro and in vivo and has cooperative activity in combination with antisense bcl-2. 113
DNA index of ovarian carcinomas from 56 different patients: in vivo, in vitro studies. 112
Growth inhibition of tumor cells by epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is associated with upregulation of p27 and p21 cyclin-dependent kinase inhibitors. 112
Critical role of both p27kip1 and p21cip1/waf1 in the antiproliferative effect of ZD1839 (‘Iressa’), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells. 111
Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells. 110
TGFb inhibits rat thyroid cell proliferation without alterations in the expression of THS-induced cell cycle-related genes. Vol :pp , 110
Expression of teratocarcinoma-derived growth factor-1 (TDGF-1) in testis germ cell tumors and its effects on growth and differentiation of embryonal carcinoma cell line NTERA2/D1. 110
Type-I isoform of PKA is involved in the control of cell proliferation and oncogene transformation of human mammary epithelial cells.Therapeutic implications 110
8-Chloro-cAMP enhances the growth inhibitory effect of cytotoxic drugs in human colon cancer cells 109
The expression of proliferating cell nuclear antigen in paraffin sections of peripheral, node-negative non-small cell lung cancer. 109
Cell growth-inhibition and cell cycle perturbations induced by a new synthetic iminoquinone, 5H-pyridophenoxazin-5-one, in human breast carcinoma cell lines. 109
DNA-flow cytometry (ploidy and S-phase fraction) as prognostic factor in a retrospectine series of 515 primary breast cancer. 108
Inhibition of NF-kB activity potentiates ionizing radiation and cisplatin induced cell killing of anaplastic thyroid carcinoma cells AACR Meeting Abstracts, Apr 2006; 2006: 1038. 107
Enzastaurin inhibits tumors sensitive and resistant to anti-EGFR drugs 106
Predictive factors of response to neoadjuvant chemoradiotherapy in rectal cancer patirnts. 106
Blast cells DNA content in childhood leukemias. 106
PRECLINICAL AND PHASE I STUDY OF OXALIPLATIN AND TOPOTECAN IN COMBINATION IN HUMAN CANCER. 106
Abstract 4017: Anti-tumor activity of a BRAF inhibitor and IFNα combination in BRAF mutant melanoma 105
Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: a phase II study. 103
Growth arrest, apoptosis and potentiation of 5-fluorouracil and Raltitrexed cytotoxic effect induced by histone deacetylase inhibitor SAHA in colorectal cancer cells. 103
POLY(ADENOSINE DIPHOSPHATE-RIBOSE) POLYMERASE 1 EXPRESSION IN MALIGNANT MELANOMAS FROM PHOTOEXPOSED AREAS OF THE HEAD AND NECK REGION. 102
Altre Neoplasie 102
Suppression of malignancy targeting the intracellular signal transducing proteins of cAMP: the use of site selective cAMP analogs, antisense strategy, and gene-transfer. 102
Synergistic inhibition of growth and induction of apoptosis by 8-chloro-cAMP and paclitaxel or cisplatin in human cancer cells. 101
IgE receptors. 100
Cell ploidy in 19 Wilms tumors by flow-cytometry of cell suspensions prepared from paraffina embedded sections. 100
Theophylline-induced apoptosis is paralleled by protein kinase A-dependent tissue transglutaminase activation in cancer cells. 100
A specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer 100
Interferon-alpha induces apoptosis in human KB cells through a stress-dependent mitogen activated protein kinase pathway death is antagonized by epidermal growth factor. 98
The farnesyltransferase inhibitor R115777 (Zanestra) synergizes with ionizing radiation in inducing cell cycle perturbation and growth inhibition of human epidermoid head and neck cancer cells. 98
Multidisciplinary Approach to Patient with Malignant Melanoma 98
Farsi promotori di salute: “Safe Sun Coast” 98
Antisense-protein kinase A: a single-gene-based therapeutic approach. 96
A Specific miRNA Signature Correlates with Complete Pathological Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer. 96
EGF-R tyrosyne kinase as new target in melanoma treatment; Synergistic effect of IFN alpha in combination with ZD1839 )Iressa) , an EGFR tyrosine kinase inhibitor. 96
P53 expression in non-small-cell lung-cancer. Clinical and biological correlations. 95
Predictive factors of complete response to neoadjuvant chemoradiotherapy in patients with rectal cancer. 94
p53 alterations in non-small cell lung cancers correlate with metastatic involvement of hilar and mediastinal lymph nodes. 94
Measurement of neovascularization is an independent prognosticator of survival in node-negative breast cancer patients with long-lerm follow-up. 94
TESI DI DOTTORATO: Hereditary and familial breast and ovarian cancer: spectrum of related tumors. CANDIDATO: M.Pensabene. RELATORE: S.Pepe 94
EPIGENETIC FACTORS IN HEREDITARY BREAST CANCER 94
Synerglstic antltumor effect by novel modified oligonucleotides targeting PKAI combined with cytotoxic drugs or monoclonal antibodies. 94
Bevacizumab maintenance in metastatic colorectal cancer: How long?. 94
Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment. 93
EGF activates an inducible survival response via the RAS -> Erk-1/2 pathway to counteract interferon-alfa-mediated apoptosis in epidermoid cancer cells. 93
Epidermal growth factor (EGFR) and Transferrin (TRFR) receptor upregulation is induced by arabinoside cytosine (ARA-C) on human tumor cells. 93
Phase I-II study of sequential combination of XELOX and bevacizumab plus erlotinib (XELOX-TARAV) in first line colorectal patients:Run in phase I part 93
Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225. 92
Twenty-year results of the Naples GUN randomized trial: predictive factors of adjuvant tamoxifen efficacy in early breast cancer. 92
Cooperative effect of 8-Cl-cAMP and rhGM-CSF on the differentiation of HL-60 human leukemia-cells. 92
REPLY TO BRCA2 SPLICE SITE MUTATIONS IN ITALIAN BREAST/OVARIAN CANCER FAMILY. 92
Retroviral vector-mediated overexpression of the RIIbeta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts. 91
Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation. 91
Totale 13.505
Categoria #
all - tutte 60.796
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 60.796


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.036 0 0 0 14 164 30 171 11 153 2 168 323
2021/20221.181 4 0 3 35 30 39 15 54 189 161 141 510
2022/20231.923 190 91 53 246 271 420 2 169 357 10 74 40
2023/20241.135 80 136 66 27 67 142 276 61 28 39 47 166
2024/20252.370 78 33 52 94 147 364 392 242 317 102 243 306
2025/20263.744 572 1.670 1.421 81 0 0 0 0 0 0 0 0
Totale 19.972