Distribuzione geografica
Continente #
NA - Nord America 2687
EU - Europa 682
AS - Asia 389
Continente sconosciuto - Info sul continente non disponibili 4
AF - Africa 1
OC - Oceania 1
SA - Sud America 1
Totale 3765
Nazione #
US - Stati Uniti d'America 2687
IT - Italia 287
CN - Cina 263
UA - Ucraina 164
IE - Irlanda 78
TR - Turchia 70
SE - Svezia 55
VN - Vietnam 53
DE - Germania 47
FI - Finlandia 29
FR - Francia 13
EU - Europa 4
CZ - Repubblica Ceca 2
PL - Polonia 2
AR - Argentina 1
AU - Australia 1
CH - Svizzera 1
ES - Italia 1
IL - Israele 1
IR - Iran 1
JP - Giappone 1
NL - Olanda 1
NO - Norvegia 1
RU - Federazione Russa 1
SC - Seychelles 1
Totale 3765
Città #
Ann Arbor 762
Chandler 389
Wilmington 284
Woodbridge 271
Princeton 230
Houston 225
Jacksonville 222
Salerno 96
Dublin 78
Beijing 70
Izmir 70
Nanjing 59
Andover 54
Dong Ket 53
Pellezzano 38
Dearborn 35
Boardman 32
Guangzhou 28
Redwood City 24
Fairfield 20
Shenyang 19
Mestre 17
Naples 15
Ashburn 13
Hebei 13
Changsha 12
Montecorvino Pugliano 12
Norwalk 12
Nanchang 11
Tianjin 10
Düsseldorf 9
San Diego 9
Redmond 8
Jinan 7
Falls Church 6
Jiaxing 6
Cava de' Tirreni 5
Pomigliano d'Arco 4
Acerra 3
Sant'angelo Romano 3
Atella 2
Cambridge 2
Fisciano 2
Hangzhou 2
Hanover 2
Lodz 2
Manduria 2
Montoro 2
Napoli 2
Ningbo 2
Palermo 2
Rome 2
Santa Maria Capua Vetere 2
Spinea 2
Taiyuan 2
Taizhou 2
Zelarino 2
Agropoli 1
Azar 1
Buenos Aires 1
Buffalo 1
Campagna 1
Casavatore 1
Cassano Allo Ionio 1
Cheboksary 1
Chongqing 1
Dormagen 1
Gragnano 1
Groningen 1
Haikou 1
Hefei 1
Indiana 1
Kunming 1
Lanzhou 1
Las Vegas 1
Lugano 1
Milan 1
Nettuno 1
Nürnberg 1
Olbia 1
Orange 1
Pavia 1
Piacenza 1
Pompei 1
Pontecagnano 1
Pozzuoli 1
Seattle 1
Shaoxing 1
Siena 1
Sturno 1
Suzhou 1
Tromsø 1
Wuhan 1
Yellow Springs 1
Zhengzhou 1
Totale 3306
Nome #
SAR study and conformational analysis of a series of novel peptide G protein-coupled receptor kinase 2 inhibitors 111
A New Series of 1,3-Dihidro-Imidazo[1,5-c]thiazole-5,7-Dione Derivatives: Synthesis and Interaction with Aβ(25-35) Amyloid Peptide 107
Biological activity of 3-chloro-azetidin-2-one derivatives having interesting antiproliferative activity on human breast cancer cell lines 105
Synthesis of novel indole-based ring systems by acid-catalysed condensation from α -amino aldehydes and L-Trp-OMe 100
Characterization of a selective CaMKII peptide inhibitor 94
Synthesis, in Vitro, and in Cell Studies of a New Series of [Indoline-3,2'-thiazolidine]-Based p53 Modulators 94
Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines 93
ChemInform Abstract: A Practical, Green, and Selective Approach Toward the Synthesis of Pharmacologically Important Quinone-Containing Heterocyclic Systems Using Alumina-Catalyzed Michael Addition Reaction 93
Design, Synthesis, and Cytotoxic Evaluation of a New Series of 3-Substituted Spiro[(dihydropyrazine-2,5-dione)-6,3‘-(2‘,3‘-dihydrothieno[2,3-b]naphtho-4‘,9‘-dione)] Derivatives 91
Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening 90
Design, Synthesis, and Cytotoxic Evaluation of Acyl Derivatives of 3-Aminonaphtho[2,3-b]thiophene-4,9-dione, a Quinone-Based System 87
A New Approach to the Synthesis of Policyclic Dipeptide Derivatives as Potential Antitumoral AgentsUnderstanding Biology Using Peptides 87
Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators 84
Unprecedented synthesis of a novel amino quinone ring system via oxidative decarboxylation of quinone-based alpha,alpha-amino esters 83
Design and synthesis of spirotryprostatin-inspired diketopiperazine systems from prolyl spirooxoindolethiazolidine derivatives 82
A practical, green and selective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems using alumina-catalyzed Michael addition reaction. 81
Identification of the Spiro(oxindole-3,3 '-thiazolidine)-Based Derivatives as Potential p53 Activity Modulators 81
Combinatorial Approach in the Synthesis of a Small Library of β-Turn Structures Based on Thiazolidine MoietyUnderstanding Biology Using Peptides 81
Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors 79
Human Glioblastoma Multiforme: p53 Reactivation by a Novel MDM2 Inhibitor 77
Conformational Stability of Aβ-(25-35) in the Presence of Thiazolidine Derivatives 77
Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor 76
Design and synthesis of small libraries of peptidomimetics based on a thiazolidine moiety 75
Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors 73
Novel route in the synthesis of ψ[CH2NH] amide bond surrogate 71
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 71
New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53 69
A novel quinone-based derivative (DTNQ-Pro) induces apoptotic death via modulation of heat shock protein expression in Caco-2 cells 69
Discovery of PTPRJ Agonist Peptides That Effectively Inhibit in Vitro Cancer Cell Proliferation and Tube Formation 68
P709 * A Novel MDM2 inhibitor, SM13, induces p53-dependent apoptosis in vascular smooth muscle cell 66
Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors 65
Dihydrithieno[2,3-b]naphto-4,9-dione analogues as anticancer agents: Synthesis and in cell pharmacological studies 65
Synthesis and pharmacological activity of 2-(substituted)-3-2-[(4-phenyl- 4-cyano)piperidino]ethyl-1,3-thiazolidin-4-ones 63
Chemical profiling of bioactive constituents in hop cones and pellets extracts by online comprehensive two-dimensional liquid chromatography with tandem mass spectrometry and direct infusion Fourier transform ion cyclotron resonance mass spectrometry 63
Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding 59
Synthesis and pharmacological evaluation of analogs of indole-based cannabimimetic agents 58
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 57
Spiro[(dihydropyrazin-2,5-dione)-6,3′-(2′,3′- dihydrothieno[2,3-b]naphtho-4′,9′-dione)]-based cytotoxic agents: Structure-activity relationship studies on the substituent at N4-position of the diketopiperazine domain 53
CaMKII protects MKP-1 from proteasome degradation in endothelial cells. 49
Bioactive polyphenols from pomegranate juice reduce 5‐fluorouracil‐induced intestinal mucositis in intestinal epithelial cells 49
Development and identification of a novel anti-HIV-1 peptide derived by modification of the N-terminal domain of HIV-1 integrase 48
A novel approach to the synthesis of diaza-bridged heterocycle derivatives 47
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 43
Cocoa Extract Provides Protection against 6-OHDA Toxicity in SH-SY5Y Dopaminergic Neurons by Targeting PERK 41
Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors 41
An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source 38
Fast profiling of natural pigments in different spirulina (arthrospira platensis) dietary supplements by DI-FT-ICR and evaluation of their antioxidant potential by pre-column DPPH-UHPLC assay 37
Ring-Fused Cyclic Aminals from Tetrahydro-β-carboline-Based Dipeptide Compounds 37
Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization 36
Cell penetrating peptides in ocular drug delivery: State of the art 35
Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators. 34
Identification of an indol-based multi-target kinase inhibitor through phenotype screening and target fishing using inverse virtual screening approach 32
Identification of a Potent Tryptophan-Based TRPM8 Antagonist with in Vivo Analgesic Activity 31
Exploration of TRPM8 Binding Sites by β-Carboline-Based Antagonists and Their in Vitro Characterization and in Vivo Analgesic Activities 31
Design, Synthesis, Biological Activity, and Structural Analysis of Lactam-Constrained PTPRJ Agonist Peptides 29
Investigation on side-product formation during the synthesis of a lactoferrin-derived lactam-bridged cyclic peptide 29
Immunomodulatory activity of Humulus lupulus bitter acids fraction: Enhancement of natural killer cells function by NKp44 activating receptor stimulation 27
Polyphenolic extract from tarocco (Citrus sinensis l. osbeck) clone “lempso” exerts anti-inflammatory and antioxidant effects via NF-KB and Nrf-2 activation in murine macrophages 26
Online comprehensive hydrophilic interaction chromatography × reversed phase liquid chromatography coupled to mass spectrometry for in depth peptidomic profile of microalgae gastro-intestinal digests 26
Characterization of phase I and phase II metabolites of hop (Humulus lupulus L.) bitter acids: In vitro and in vivo metabolic profiling by UHPLC-Q-Orbitrap 25
β -Lactoglobulin Heptapeptide Reduces Oxidative Stress in Intestinal Epithelial Cells and Angiotensin II-Induced Vasoconstriction on Mouse Mesenteric Arteries by Induction of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Translocation 21
null 19
Therapeutic potential of TRPM8 antagonists in prostate cancer 14
Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification 14
Discovery of a novel tetrapeptide against influenza a virus: Rational design, synthesis, bioactivity evaluation and computational studies 11
Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure 10
In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening 9
MALDI Mass Spectrometry Imaging Highlights Specific Metabolome and Lipidome Profiles in Salivary Gland Tumor Tissues 9
Development and application of a fast ultra-high performance liquid chromatography-trapped ion mobility mass spectrometry method for untargeted lipidomics 8
Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity 7
New TRPM8 blockers exert anticancer activity over castration-resistant prostate cancer models 5
In Silico Identification and In Vitro Evaluation of New ABCG2 Transporter Inhibitors as Potential Anticancer Agents 4
N-substitued tryptamines as TRPM8 channel modulators 4
New Frontiers on ER Stress Modulation: Are TRP Channels the Leading Actors? 3
Pursuing the Development of New Antiviral Entry Inhibitors 2
N-4 Alkyl cytosine derivatives synthesis: a new approach 2
Pursuing the Development of New Antiviral INSTIs 2
DTNQ-based anticancer derivatives as selective glucose penetration inhibitors 2
Synthesis of a New Series of [Indoline3, 2’-thiazolidine] - Based p53 modulators 2
Characterization of New TRPM8 Modulators in Pain Perception 2
Continuous-flow synthesis of thiazolidine libraries: one-pot two steps protocol optimization 2
Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization 2
N-substituted tryptamines as TRPM8 channel modulators 1
Totale 3944
Categoria #
all - tutte 6757
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 6757

Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2017/2018365 0000 00 0225 2766641
2018/2019334 24233425 1261 1020 1615886
2019/2020525 123185511 2615 4610 43758518
2020/2021443 431404 5031 529 10164867
2021/2022423 5206 346 616 635454177
2022/2023665 7312128111 104196 1715 0000
Totale 3944